نتایج جستجو برای: proline dehydrogenase prodh
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Catabolism of proline is widespread in prokaryotes and in mitochondria of eukaryotic cells. In enteric bacteria, the putA gene encodes a membrane-associated dehydrogenase (EC 1.5.99.8) that oxidizes proline to glutamate for use as the sole carbon, nitrogen or energy source (5). In addition, PutA protein also functions as the autogenous transcriptional repressor of the put operon (6, 10). The st...
Many enzymes form homooligomers, yet the functional significance of self-association is seldom obvious. Herein, we examine the connection between oligomerization and catalytic function for proline utilization A (PutA) enzymes. PutAs are bifunctional enzymes that catalyze both reactions of proline catabolism. Type A PutAs are the smallest members of the family, possessing a minimal domain archit...
Pro dehydrogenase (PDH) catalyzes the first and rate-limiting step in the Pro catabolic pathway. In Arabidopsis, this enzyme is encoded by At-PDH. To investigate the role of Pro catabolism in plants, we generated transgenic Arabidopsis plants with altered levels of PDH by sense (PDH-S plants) and antisense (PDH-AS plants) strategies. Free Pro levels were reduced by up to 50% in PDH-S plants und...
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes. To further evaluate the roles of the associated variants in the disorder, we have conducted magnetic resonance imaging (MRI) sc...
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