نتایج جستجو برای: proline

تعداد نتایج: 16875  

Journal: :Journal of bacteriology 1966
L Unger R D DeMoss

Unger, Leon (University of Illinois, Urbana), and R. D. DeMoss. Action of a proline analogue, l-thiazolidine-4-carboxylic acid, in Escherichia coli. J. Bacteriol. 91:1556-1563. 1966.-The effect of the proline analogue, l-thiazolidine-4-carboxylic acid (thioproline), on growth, and its relation to the metabolic function of proline in protein synthesis in Escherichia coli K-12, has been studied. ...

Journal: :The Journal of Cell Biology 2003
Nicole LeBrasseur

new report shows that a eukaryotic transcription factor is directly activated by a metabolite of the pathway it controls. Although this idea has been proposed for several regulatory systems, Christopher Sellick and Richard Reece (University of Manchester, UK) are the first to demonstrate direct binding to and activation of a eukaryotic transcription factor by a small molecule metabolite. The in...

Journal: :Infection and immunity 2008
Navasona Krishnan Alan R Doster Gerald E Duhamel Donald F Becker

Helicobacter hepaticus is a gram-negative, spiral-shaped microaerophilic bacterium associated with chronic intestinal infection leading to hepatitis and colonic and hepatic carcinomas in susceptible strains of mice. In the closely related human pathogen Helicobacter pylori, L-proline is a preferred respiratory substrate and is found at significantly high levels in the gastric juice of infected ...

2016
Tong Zhou Luke Erber Bing Liu Yankun Gao Hai-Bin Ruan Yue Chen

Proline hydroxylation is a critical cellular mechanism regulating oxygen-response pathways in tumor initiation and progression. Yet, its substrate diversity and functions remain largely unknown. Here, we report a system-wide analysis to characterize proline hydroxylation substrates in cancer cells using an immunoaffinity-purification assisted proteomics strategy. We identified 562 sites from 27...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2008
Konstantina V Kocheva Georgi I Georgiev

The amino acid proline is accumulated in plant tissues in response to a variety of stresses. The existence of two routes for its biosynthesis is well documented. However, little is known about the contribution of each pathway to the accumulation of free proline under stress conditions. In the present study young barley plants were subjected to osmotic stress by treating their roots with 25% pol...

Journal: :The Journal of Cell Biology 2003
Nicole LeBrasseur

new report shows that a eukaryotic transcription factor is directly activated by a metabolite of the pathway it controls. Although this idea has been proposed for several regulatory systems, Christopher Sellick and Richard Reece (University of Manchester, UK) are the first to demonstrate direct binding to and activation of a eukaryotic transcription factor by a small molecule metabolite. The in...

Journal: :The Biochemical journal 1996
C C Lawrence W J Sobey R A Field J E Baldwin C J Schofield

Proline 4-hydroxylase is a 2-oxoacid, ferrous-ion-dependent dioxygenase involved in the biosynthesis of the secondary metabolite etamycin. The purification, in low yield, of proline 4-hydroxylase from Streptomyces griseoviridus P8648 to near, apparent homogeneity and its initial characterization are reported. In most respects proline 4-hydroxylase is a typical member of the 2-oxoacid-dependent ...

2015
Wei Liu Chad N. Hancock Joseph W. Fischer Meredith Harman James M. Phang

The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at both protein and mRNA levels. Blockade of PB decreases tumor cell growth and energy production. Addition of Δ(1)-pyrroline-5-carboxylate (P5C) or pro...

Journal: :Plant, cell & environment 2006
D Verdoy T Coba De La Peña F J Redondo M M Lucas J J Pueyo

Legume root nodule nitrogen-fixing activity is severely affected by osmotic stress. Proline accumulation has been shown to induce tolerance to salt stress, and transgenic plants over-expressing Delta(1)-pyrroline-5-carboxylate synthetase (P5CS), which accumulates high levels of proline, display enhanced osmotolerance. Here, we transformed the model legume Medicago truncatula with the P5CS gene ...

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