Diabetic retinopathy and nephropathy cause significant morbidity in patients with diabetes. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications. We previously reported transfection studies showing the VEGF -460 and VEGF +405 polymorphisms to increase basal VEGF promoter activity by 71% compar...

BACKGROUND The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy. METHODS In this retrospective observational study, diabetic patient...

objective(s):to the best of our knowledge, this is the first report on the contributions of gst genetic variants to the risk of diabetic retinopathy in an iranian population. therefore, the objective of this study was to determine whether sequence variation in glutathione s-transferase gene (gstm1 and gstt1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (t2d...

BACKGROUND Atherogenic lipoproteins, such as total cholesterol, LDL cholesterol, oxidized low density lipoprotein, and triglycerides, are associated with progression of retinopathy. Aim. To evaluate the relationship between lipoprotein(a) and retinopathy in patients with type 2 diabetes mellitus. MATERIALS AND METHODS We enrolled 145 diabetic consecutive patients (82 females, 63 males; mean a...

The present study was conducted to find out the role of serum lipids in the development of diabetic retinopathy in type II Diabetes Mellitus. One hundred fifty subjects aged 30-70 years attending OPD at Old Civil hospital, Surat, participated in the study and were divided into three groups. Group I included 50 healthy non-diabetic subjects who served as control. Group II included 50 diabetic su...

Advanced diabetic retinopathy with vitreous hemorrhage or tractional retinal detachment (TDR) is an important cause of severe visual loss in patients with proliferative diabetic retinopathy (PDR), frequently representing an indication for pars plana vitrectomy in diabetic patients. In these cases, surgery is not free from complications such as intraoperative vitreous hemorrhage and retinal rupt...

Retinal image analysis is an essential step in the diagnosis of various eye diseases. Diabetic Retinopathy (DR) is globally the primary cause of visual impairment and blindness in diabetic patients. Early diagnosis through regular screening and timely treatment has proven beneficial in preventing visual impairment and blindness. In this paper we have proposed a novel approach to automatically d...

Diabetic Retinopathy (DR) is globally the primary cause of visual impairment and blindness in diabetic patients. Diabetic retinopathy occurs when the small blood vessels have a high level of glucose in the retina. That causes a change in the retina, which occur over a period of time in diabetics and cause the difficulties with vision. Regular screening is essential in order to detect the early ...

BACKGROUND There is a high hospitalization rate for diabetic patients. Since retinopathy and albuminuria are both important manifestations of microvascular disease in diabetes, our aim was to investigate the effect of retinopathy and albuminuria on long-term mortality in type 2 diabetic inpatients through this observational cohort study. METHODS Type 2 diabetic inpatients given a primary diag...

AIM To determine the staining pattern of vascular endothelial growth factor (VEGF) at different stages of diabetic retinopathy (including post-laser photocoagulation) and to compare staining in excised fibrovascular and fibrocellular (non-diabetic) preretinal membranes. METHODS Immunohistochemical localisation of VEGF, using antibodies raised against VEGF165 and VEGF121,165,189, was carried o...