Abstract Background Long non-coding RNA is considered to be essential modulate the development and progression of human malignant cancers. And long can act as crucial modulators by sponging corresponding microRNA in tumorigenesis. We aimed elucidate function ACTA2-AS1 its molecular mechanism colon adenocarcinoma. Materials methods The expression ACTA2-AS1, miR-4428 BCL2L11 adenocarcinoma tissue...

Preeclampsia (PE) is a severe pregnancy-specific complication responsible for majority of maternal and fetal mortality. The dysfunction trophoblast cells known to be associated with the etiology PE. Moreover, elevated expression hsa_circ_0001326 was found in patients PE without elucidating specific mechanisms. Thus, this study aimed investigate role vitro. Human SWAN71 were used study. Cell pro...

Background: Iron is an essential trace element in cell proliferation. Several investigations demonstrate that iron deprivation inhibits cell proliferation. However, the impact of iron on telomerase activity of activated lymphocytes remains unexplained to date. Objective: In this study, the effect of iron on the proliferation and telomerase activity of lymphocytes stimulated by phytohemagglutini...

G protein-coupled receptor 56 (GPR56) belongs to the adhesion subfamily, which plays a role in cell progression and survival. The aim of this study was investigate GPR56 gene line impact its protein expression on prognosis colorectal cancer (CRC) patients. effect tumor proliferation (WST-1 assay), invasion (Transwell migration assay, wound healing colony-forming ability (semisolid agar assay) e...

objective: the development of combining mesenchymal stem cells (mscs) with surface modified three-dimensional (3d) biomaterial scaffold provides a desirable alternative for replacement of damaged and diseased tissue. nanofibrous scaffolds serve as suitable environment for cell attachment and proliferation due to their similarity to the physical dimension of the natural extracellular matrix. in ...

Introduction. Bladder cancer (BCa) is one the most common urinary system malignancies and approximately quarter of diagnosis invasive muscle-invasive BCa. Accumulating evidence revealed that keratin 17 (KRT17) closely related to prognosis progression various tumors including a recent study also implying potential role KRT17 in However, specific BCa remains be elucidated. Material methods. The e...

Purpose: To investigate the effect of microribonucleic acid (miR)-26 targeting methyltetrahydrofolate reductase (MTHFR) on cell proliferation, cycle, and apoptosis in acute myeloid leukemia (AML).Methods: The expressions miR-26 three types human AML lines (HL-60, Kasumi-1, KG-1a) normal line (HS-5) were determined via quantitative reverse transcriptionpolymerase chain reaction (qRT-PCR), while ...

Abstract BACKGROUND Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), each potentially a possible therapeutic target treating AT/RT. Thus, targeting distinct histone modifier activities would be effective approach METHODS The effects inhibition on modification, cell proliferation, invasion were analyzed by immun...

Background Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are associated with the pathogenesis atherosclerosis (AS). Eplerenone (EPL), a novel selective aldosterone receptor blocker, plays substantial role in treatment cardiovascular disease. The G protein-coupled estrogen (GPER) is target EPL as STITCH website predicated. Objectives We aimed to investigate roles ...