Transcriptional regulation of the prolactin gene in the decidua differs from that in the pituitary. Several lines of evidence strongly suggest this difference is due to regulation of the prolactin gene in the decidua and other extra-pituitary tissues by tissue-specific transcription factors, which activate distinct promoters to induce prolactin gene expression in extra-pituitary sites compared ...

BACKGROUND Patients with intellectual disabilities may be treated with antipsychotic medications for a variety of diagnoses. Use of this category of medication can increase prolactin levels and place the patient at risk for sexual dysfunction and lower bone mineral density. The proposed mechanism of action is affinity for the dopamine receptor. Use of bromocriptine, a dopamine receptor antagoni...

Chamomile is a fascinating plant quoted in several traditional medicine texts, which hasbroad-spectrum pharmacological activity and medicinal uses. The aim of this study was toassess the efficacy of chamomile syrup in reducing serum prolactin in women with idiopathichyperprolactinemia. The study was a randomized, controlled clinical trial that was cond...

Mother's milk is considered the optimal substance for newborns because it provides complete nutrition, improves infant health, and increases immunity low incidence of gastrointestinal disease. The development alveolar-lobular glands in breast initiation breastfeeding role prolactin hormone. Genistein a type isoflavonoid whose content abundant soybeans, their processed products (tempeh tofu) pla...

STUDY QUESTION Is there an association between prolactin and markers of metabolic risk in polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Low serum prolactin was a metabolic risk marker in PCOS. WHAT IS KNOWN ALREADY Prolactin is routinely measured to exclude endocrine diseases in PCOS. Recent studies have suggested that prolactin can be used as a marker for metabolic and cardiovascular ri...

We studied the prolactin response to TRH in 53 unmedicated psychiatric inpatients. The prolactin response of females was significantly greater than the response of male subjects. There was no significant difference in the prolactin response to TRH between depressed patients and those with other psychiatric diagnoses. There was no significant relationship between the prolactin response to TRH an...

GH4C1 cells (CH cells) are a clonal strain of rat pituitary tumor cells which secrete prolactin. We measured intracellular prolactin at different stages of the cell cycle using flow microfluorometry. Prolactin was stained by an indirect immunocytochemical technique using fluorescein isothiocyanate (FITC)-conjugated antiserum, and DNA was stained simultaneously with propidium iodide. We found th...

ANDI (Aberration of normal development and involution) classification covers most of the benign breast conditions as a result of hormonal influence. Prolactin plays an important role in normal proliferation and differentiation of breast epithelium. The objective of this hospital based study was to find out clinical presentation and prolactin level of ANDI patients. Total 330 patients with diffe...