Running Title: Non-obese F-DIO rats are insulin resistant ABSTRACT We previously created a novel F-DIO rat strain derived by crossing rats selectively bred for the diet-induced obese (DIO) phenotype with obesity-resistant Fischer F344 rats. The offspring retained the DIO phenotype through 3 backcrosses with F344 rats but also had exaggerated insulin responses to oral glucose before they became ...

Maternal obesity and genetic background can affect the development of obesity and diabetes in offspring. Here we used selected strains of rats resistant (DR) vs. susceptible to development of diet-induced obesity (DIO) on high-energy (HE) diets to assess this issue. DR and DIO dams were fed either Chow or HE diet for 4 wk. DIO HE diet-fed dams and additional DR rats fed a palatable liquid diet ...

The objective of this study was to determine the potential role of astrocyte-derived ketone bodies in regulating the early changes in caloric intake of diet induced-obese (DIO) versus diet-resistant (DR) rats fed a 31.5% fat high-energy (HE) diet. After 3 days on chow or HE diet, DR and DIO rats were assessed for their ventromedial hypothalamic (VMH) ketone bodies levels and neuronal ventromedi...

Ha un senso parlare oggi di diritto e Sacra Scrittura? E cercare capire come può questo rapporto aiutare l’uomo moderno nel suo anelito verso la verità, con Dio?
 Il non prescindere dalla Scrittura che, in quanto Parola Dio, va sempre tenuta presente, sia da parte dei giuristi che politici cattolici, nella gestione del bene comune.
 Chiesa trova il fondamento Scrittura, è dono Dio att...

Of the parameters that determine glucose disposal and progression to diabetes in humans: first-phase insulin secretion, glucose effectiveness (Sg), insulin sensitivity (Si), and the disposition index (DI), only Si can be reliably measured in conscious mice. To determine the importance of the other parameters in murine glucose homeostasis in lean and obese states, we developed the frequently sam...

There are errors in the Funding section. The publisher apologizes for the errors. The correct funding information is as follows: This work was supported by NeuroScreen (FP6, European Union Health-2007-B-222943) and Progetto Giovani Ricercatori (Italian Ministry of Health, GR-2008-1146615) to Luciano Conti and by Progetto Oncologico “Characterization of the molecular mechanisms regulating brain ...

Diosmetin (Dio) is a major active component of flavonoid compounds. A previous study demonstrated that Dio exhibited anticancer activity and induced apoptosis in HepG2 human hepatoma cells via cytochrome P450, family 1-catalyzed metabolism. The present study observed that cell proliferation of HepG2 cells was inhibited by Dio treatment and tumor protein p53 was significantly increased following...