Hui-Bing Katie Wu, PhD; Tipyamol Niyomchai, PhD; Eugene Festa, PhD; AnaChristina E. Minerly, PhD; Karen Weierstall, PhD; Deirtra Hunter, MA; Weilun Sun, MA; Jan Weiner, BA; Shirzad Jenab, PhD; Vanya Quinones-Jenab, PhD Evidence suggests that sex differences in response to cocaine administration may be regulated by activation of progesterone and estrogen receptors. To test this hypothesis, rats ...

Evidence suggests that sex differences in response to cocaine administration may be regulated by activation of progesterone and estrogen receptors. To test this hypothesis, rats were pretreated with either RU 486 (progesterone antagonist; 0, 3, or 25 mg/kg), tamoxifen (estrogen antagonist; 0, 1, or 3 mg/kg), or vehicle followed by saline or cocaine administration (15 mg/kg). Although RU 486 did...

OBJECTIVE To determine the progesterone receptor status in thyroid gland. METHODS This study was based on immunohistochemical staining of formalin fixed paraffin embedded tissues, for progesterone receptors, in 50 previously diagnosed cases of various thyroid lesions and surrounding normal thyroid tissue. RESULTS Out of 50 cases, 8 were nodular goiter, 9 cases of adenoma, 19 papillary carci...

OBJECTIVE To evaluate the immunoexpression of estrogen and progesterone receptors in biopsies and surgical specimens of patients with breast cancer before and after neoadjuvant chemotherapy and to correlate their changes with the pattern of response to chemotherapy and diagnosis of menopause. METHODS We selected 47 patients with histological diagnosis of locally advanced primary breast carcin...

The binding of estradiol to nuclear fractions extracted from human breast carcinomatous tissue was demonstrated. The material, which was extracted with KCl, had an approximate molecular weight of 37,000 and bound estradiol with both high and low affinity (Kd congruent to 1 nM, type A receptors; Kd congruent to 30 nM, type B receptors) as calculated according to the method of Scatchard. Competit...

Endocrinologic and metabolic abnormalities in polycystic ovary syndrome (PCOS) may have complex effects on the endometrium, contributing to the infertility endometrial disorders observed women with this  syndrome. The consequences of PCOS on homeostasis pathophysiology not been comprehensively understood. This review provides an overview molecular mechanisms endometrial  function with this path...

A number of synthetic and naturally occurring steroids were studied for competitive binding to two progesterone receptors, one in chick oviduct and another in human uterus. The results show a good correlation of relative (to progesterone) binding affinity with progestational activity as measured by subcutaneous Clauberg assay. 17a-Ethynyltestosterone and closely related compounds compete very w...

Insulin and insulin like-growth factor-I (IGF-I) participate in the regulation of ovarian steroidogenesis. In insulin resistant states ovaries remain sensitive to insulin because insulin can activate alternative signaling pathways, such as phosphatidylinositol-3-kinase (PI-3 kinase) and mitogen-activated protein-kinase (MAPK) pathways, as well as insulin receptors and type 1 IGF receptors. We i...

Pleomorphic variant of lobular carcinoma is a recently described variant of invasive lobular carcinoma. It is reported to be positive for estrogen receptors and progesterone receptors and over express Her2/neu in most cases. We present here a case of invasive variant of pleomorphic lobular carcinoma with coexisting classic and pleomorphic variants of lobular carcinoma in situ along with focal d...