BACKGROUND MRI is often used as primary outcome measure in phase II clinical trials in multiple sclerosis (MS). Since persistent T1 hypointense lesions are a surrogate parameter for axonal damage and demyelination, they may serve as a marker for monitoring the efficacy of neuroprotective drugs. At present, a power analysis using black hole (BH) evolution as primary outcome measure has not been ...

  Honey is a by-product of flower nectar and the upper aero-digestive tract of the honey bee, which is concentrated through a dehydration process inside the bee hive. Honey has a very complex chemical composition that varies depending on the botanical source. It has been used both as food and medicine since ancient times. Human use of honey is traced to some 8000 years ago as depicted by Stone ...

It has normally been assumed that primordial black holes (PBHs) always form with mass approximately equal to the mass contained within the horizon at that time. Recent work studying the application of critical phenomena in gravitational collapse to PBH formation has shown that in fact, at a fixed time, PBHs with a range of masses are formed. When calculating the PBH initial mass function it is ...

Objective To compare the periodontal bone height (PBH) of exclusive narghile smokers (ENS) with that of exclusive cigarette smokers (ECS). Methods Tunisian males aged 20-35 years who have been ENS for more than five narghile-years or ECS for more than five pack-years were recruited to participate in this comparative cross-sectional study. Information about oral health habits and tobacco consump...

new sources of maize resistance to the maize weevil, sitophilus zeamais infestation are indispensable in successful breeding programs against post harvest grain damage. the study investigated the characters and mechanisms that confer resistance to weevil infestation using twenty elite maize genotypes. detailed morphological and physical studies were conducted on whole-maize grain. the grain hul...

We consider a model of static cosmic string loops in type IIB string theory, where the strings wrap cycles within the internal space. The strings are not topologically stabilised, however the presence of a lifting potential traps the windings giving rise to kinky cycloops. We find that PBH formation occurs at early times in a small window, whilst at late times we observe the formation of dark m...

The aim of this study was to explore the spatiotemporal development of cerebral oedema in the early stage of severe burn (50% TBSA, third degree), using a four-dimensional (4D) mathematical model. Twenty-six male mongrel dogs were randomly divided into control and 6, 12, 18, and 24 post-burn hour (PBH) groups. The manifestation of magnetic resonance imaging (MRI) and histopathology, changes of ...

Stephen Hawking’s prediction that black holes should radiate like black bodies has several important consequences, including the possibility of the detection of small (∼1015 g) black holes created in the very early universe. The detection of such primordial black holes (PBHs) would be an important discovery, not only confirming Hawking’s theory, but also providing valuable insights into the his...