mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. several recombinant protein systems have been introduced to the market, most of which are under clinical development. in spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

This article provides an economic explanation regarding why the share of U.S. pork raised on company-owned farms with hired management (integration) is increasing relative to production through independently owned-and-operated contract growers (contracting). The article develops a property rights model that shows how in certain circumstances production contracts do not transfer sufficient contr...

This paper describes the development of a hierarchical planning and scheduling system for a multiple plant, multiple product, seasonal demand situation. In this hierarchical structure, optimal decisions at an aggregate level (planning) provide constraints for detailed decision making (scheduling). Four levels of decision making are used: first, products are assigned to plants (using mixed-integ...

In this paper I explore some of the inter-relations between the globalisation of production systems, the political-economic re-definition of Europe and the changing character of places within it, and the changing character of corporate (dis)investment strategies. International investment form constitutive moments in the creation of global production systems and of changing geographies of produc...

Effective deployment and operation of flexibly automated production systems is of ever-increasing importance in contemporary competitive manufacturing. Yet, currently we lack an adequate methodology for effective deployment, reconfiguration and control of these systems, partly due to the fact that past research has not systematically modeled and analyzed the logical/structural aspects character...

With the switch from analog to digital technology the entire process of production, distribution, and archival of a film and tv program large amounts of data are created. Besides recorded and processed audiovisual information, in each single step of the production process and furthermore throughout the entire media value chain new metadata is created, administrated, and put into relation with a...

Worldwide there are between 10 and 11 million hectares of coconuts. With the marked fluctuations and long term decline in copra and coconut oil prices the integration of livestock and coconuts is economically increasingly attractive. Traditionally used for weed control in plantations so that coconuts could be located, cattle (and sheep and goats) are increasingly seen as important parts of the ...