Evaluation of failure probability of a given system requires sampling of the system response and can be computationally expensive. Therefore it is desirable to construct an accurate surrogate model for the system response and subsequently to sample the surrogate model. In this paper we discuss the properties of this approach. We demonstrate that the straightforward sampling of a surrogate model...

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases. EETs and HETEs often have opposite biologic effects; EETs are vasodilatory and protect against ischemia/reperfusion injury, while ω-terminal HETEs are vasoconstrictive and cause vascular dysfunction. Other oxylipins...

In order to stress test loan portfolios for the impacts of climate change, historical events need be analyzed create templates future events. Using 2012 Midwestern US drought as an example, this work creates a stress-testing template droughts. The analysis connects weather and crop yield data on local macroeconomic conditions by comparing drought-impacted agricultural counties with nearby urban...

This paper studies the determinants and behavior of outstanding mortgage loan to value (LTV) ratios for a panel data set of 8867 Dutch households over the period 1992-2005. We find that outstanding LTVs are driven by household characteristics, life-cycle effects and mortgage type characteristics. LTV declines with the time elapsed since mortgage commencement, but this decline is faster for soca...

The effects of atrial natriuretic peptide (ANP) on transmural myocardial blood flow distribution and the reactive hyperemic response in the presence and absence of flow-limiting coronary stenosis were examined in chronically instrumented conscious dogs. Ten-second coronary occlusion without subsequent flow restriction resulted in marked reactive hyperemic responses (Doppler flow probes), mean f...

Utilizing the gathered failure data and failure interval data from Tabas coal mine in two years, this paper discusses the reliability of powered supports. The data sets were investigated using statistical procedures and in two levels: the existence of trend and serial correlation. The results show that the powered supports follow the Gamma reliability function. The reliability of the machine de...

Design and operation of complex engineering systems rely on reliability optimization. Such optimization requires us to account for uncertainties expressed in terms complicated, high-dimensional probability distributions, which only samples or data might be available. However, using often degrades the computational efficiency, particularly as conventional failure is estimated indicator function ...