Ordered sheaves on a small quantaloid Q have been defined in terms of Q-enriched categorical structures; they form a locally ordered category Ord(Q). It has previously been shown by the second author that the " free-cocompletion " KZ-doctrine on Ord(Q) has Mod(Q), the quantaloid of Q-modules, as category of Eilenberg-Moore algebras. In the first part of this paper we apply Q-enriched category t...

For any n ≥ 2 we study the group algebra decomposition of an ([ 2 ] + 1)dimensional family of principally polarized abelian varieties of dimension n with an action of the dihedral group of order 2n. For any odd prime p, n = p and n = 2p we compute the induced polarization on the isotypical components of these varieties and some other distinguished subvarieties. In the case of n = p the family c...

Molecular profiling of primary tumors may facilitate the classification of patients with cancer into more homogenous biological groups to aid clinical management. Metabolomic profiling has been shown to be a powerful tool in characterizing the biological mechanisms underlying a disease but has not been evaluated for its ability to classify cancers by their tissue of origin. Thus, we assessed me...

PURPOSE APC*I1307K (c.3920T>A) is an inherited variant associated with colorectal tumour risk found almost exclusively in those of Ashkenazi Jewish ancestry. A single nucleotide substitution creates an oligo-adenine tract (A8) that appears to be inherently prone to further mis-pairing and slippage. The reported multiple tumor phenotype of carriers is not easily reconciled with molecular and pop...

Timolol has mainly been used topically for the treatment of glaucoma. It has been suggested that the drug is metabolized by cytochrome P450 CYP2D6. The matter has not, however, been extensively studied. The aim here was to tentatively identify timolol metabolites and to determine the P450-associated metabolic and interaction properties of timolol in vitro. Four metabolites were identified, the ...