I Atherosclerosis, first, and hypertension, second, constitute the most common therapeutic problems of our time, considerably outranking cancer in incidence. Whereas little progress has been made in reducing the mortality rate from atherosclerosis or cancer, deaths from hypertension have fallen significantly over the past fifteen years, and the favorable trend is continuing. Antihypertensive dr...

Studies were carried out in 14 patients with primary aldosteronism (1°A) to examine the mechanism(s) by which spironolactone reduces arterial pressure. Measures that produced salt and water depletion were found to consistently reduce arterial pressure. Plasma volume and arterial pressure correlated directly and significantly, r =+0.509 (P <0.001), whether pressure was reduced by spironolactone ...

OPINION STATEMENT Primary central nervous system lymphoma is a particular challenge in clinical neuro-oncology. In contrast to most other malignant brain tumors, it may be considered a curable disease at least in younger patients who can tolerate intensive treatment regimens. Yet, therapeutic progress has been limited with little measurable improvement in outcome over the last two decades, main...

Primary amenorrhoea is a symptom with an extensive list of underlying causes, the majority of which are rare. By definition it should present in adolescence, although some conditions diagnosed in childhood may anticipate the failure of onset of menstruation. Many causes of secon­ dary amenorrhoea can also present with primary amenorrhoea if they arise sufficiently early. This review addresses s...