OBJECTIVE To test the hypothesis that the retinal pigment epithelial/photoreceptor complex is affected in patients with pigment dispersion syndrome and/or in patients with pigmentary glaucoma. METHODS Electro-oculograms were recorded from patients with pigment dispersion syndrome, pigmentary glaucoma, ocular hypertension, and primary open-angle glaucoma and from control subjects. Electro-ocul...

Congenital ectropion uveae (CEU) is a rare, nonprogressive condition scarcely mentioned in the ophthalmic literature. According to its etiology, ectropion is classified into 2 groups: acquired and congenital. It is believed that the cause of acquired ectropion is membranous traction of the iris from secondary causes such as inflammation and ischemia. According to Dowling et al, the term congeni...

PURPOSE Pediatric glaucoma is a rare, potentially blinding condition, yet, in the United Kingdom, there is a paucity of contemporary epidemiologic and clinical data regarding this condition. The British Infantile and Childhood Glaucoma (BIG) Eye Study is the first national population-based study conducted to examine the incidence, detection patterns, current management, and intraocular pressure...

PURPOSE To determine the distribution of CYP1B1 gene mutations in Brazilian patients with primary congenital glaucoma (PCG). METHODS PCG diagnosis was established by presence of buphthalmos in at least one affected eye and associated high intraocular pressures before the age of 3 years. CYP1B1 mutation screening of 52 patients with PCG was performed by SSCP and direct sequencing of PCR fragme...

Glaucoma is an irreversible form of optic neuropathy in which the optic nerve suffers damage in a characteristic manner with optic nerve cupping and retinal ganglion cell death. Primary congenital glaucoma (PCG) is an idiopathic irreversible childhood blinding disorder which manifests at birth or within the first year of life. PCG presents with a classical triad of symptoms (viz epiphora, photo...

Glaucoma, an optic neuropathy characterized by progressive visual field loss, is the leading cause of irreversible blindness worldwide. The condition has a substantial heritable basis, as illustrated by the numerous loci and genes identified to date and the large proportion of patients with positive family history. When glaucoma manifests before the age of 40 years, it tends to be more aggressi...

A 3-month-old girl was diagnosed with primary congenital glaucoma (PCG) at birth. She was born via normal vaginal delivery and was the first child of healthy non-related parents. Ocular findings at birth are listed in Table 1. She underwent trabeculotomy in the superonasal and inferotemporal quadrants of both eyes in one session. The results of examination six weeks after the operation are show...