The alternative pathway of the complement cascade plays a role in the pathogenesis of dense deposit disease (DDD). Deficiency of complement factor H and mutations in CFH associate with the development of DDD, but it is unknown whether allelic variants in other complement genes also associate with this disease. We studied patients with DDD and identified previously unreported sequence alteration...

Systemic lupus erythematosus (SLE) is an autoimmune disease with broad clinical manifestations characterized by the production of autoantibodies1 which can have multi -organ involvement2 with tissue damage produced mainly by complement activation by immune complexes (IC).3 As a result of this activation, patients present hypocomplementaemia during disease flares, but C3 and C4 levels are expect...

The phenotype of NFATc2(-/-) c3(-/-) (double knockout [DKO]) mice implies a disturbed regulation of T cell responses, evidenced by massive lymphadenopathy, splenomegaly, and autoaggressive phenomena. The population of CD4(+) CD25(+) T cells from DKO mice lacks regulatory capacity, except a small subpopulation that highly expresses glucocorticoid-induced tumor necrosis factor receptor family-rel...

Familial hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) carry a very poor outcome and have been reported in association with decreased serum levels of the third complement component (C3). Uncontrolled consumption in the microcirculation, possibly related to genetically determined deficiency in factor H—a modulator of the alternative pathway of complement activatio...

introduction bacillus calmette-guérin (bcg) vaccine, a live attenuated mycobacterium bovis strain, is administrated to all newborn infants in endemic regions according to the current world health organization (who) recommendation. case presentation we report a 10-month-boy who was a known case of severe combined immunodeficiency (scid) admitted with multi-focal fusiform painful swelling in his ...

We report a rare case involving a patient with C3 vertebral body metastasis secondary to adenoid cystic carcinoma of the tongue.Five years after local resection of the primary tumor, magnetic resonance imaging showed a metastasis located in the left posterior border of the C3 vertebral body. Additionally, multiple pulmonary metastases were identified by computed tomography. Based on these findi...

Let C be a circle divided into n parts equally. S = {P0, P1, . . . , Pn−1} denotes the set of the ends of these parts on C. Let C3(n) be the number of incongruent triangles inscribed in C, where the vertices of the triangles are chosen from S. In this note, we shall show a relation between the number C3(n) and the partitions into at most three parts. 2000 Mathematics Subject Classification. Pri...