Abstract Protein arginine methyltransferase-1 (PRMT1) is an important epigenetic regulator of cell function and contributes to inflammation remodeling in asthma a type–specific manner. Disease-specific expression patterns microRNAs (miRNA) are associated with chronic inflammatory lung diseases, including asthma. The de novo synthesis miRNA depends on the transcription primary (pri-miRNA) transc...

in this paper, we investigate various kinds of extensions of twin-good rings. moreover, we prove that every element of an abelian neat ring r is twin-good if and only if r has no factor ring isomorphic to z2  or z3. the main result of [24] states some conditions that any right self-injective ring r is twin-good. we extend this result to any regular baer ring r by proving that every element of a...

The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1 (ABL) phosphorylates DGCR8 to stimulate the cleavage of a subset of pro-apoptotic pri-miRNAs, th...

We des ribe a xed point approa h for the following sto hasti optimization problem: given a multi ast tree and probability distributions of user utilities, ompute pri es to o er the users in order to maximize the expe ted pro t of the servi e provider. We show that any optimum pri ing is a xed point of an eÆ iently omputable map. In the language of lassi al numeri al analysis, we show that the n...

This paper presents an automatic de-identification system for Serbian, grounded on a rapid adaptation of the existing named entity recognition system. Based on a finite-state methodology and lexical resources, the system is designed to detect and replace all explicit personal protected health information present in the medical narrative texts, while still preserving all the relevant medical con...

T he genomes of higher eukaryotes encode not only proteins but also diverse noncoding RNAs, particularly small (20to 30-nt) regulatory RNAs (1–3). The small RNAs include microRNAs (miRNAs), siRNAs, and piwi-interacting RNAs (piRNAs) (4, 5). These small RNAs repress gene expression at the transcriptional or posttranscriptional levels and have critical functions in genome defense, growth, develop...

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the concept of fuzzy soft γ-ring is introduced; and some properties of fuzzy soft γ-rings are given. then the definitions of fuzzy soft γ-ideals are proposed and some of their theories are considered.

BACKGROUND/AIM Colchicine (COL) is a well-known and potent microtubule targeting anticancer agent. The purpose of our study was to identify conditions that increase sensitization of COL-resistant cancer cells that overexpress P-glycoprotein (P-gp). MATERIALS AND METHODS The anti-malarial drugs chloroquine (CHL), mefloquine (MEF) and primaquine (PRI) have been shown to increase sensitization i...