Sandwich-cultured primary rat hepatocytes are often used as an in vitro model in toxicology and pharmacology. However, loss of liver-specific functions, in particular, the decline of cytochrome P450 (P450) enzyme activity, limits the value of this model for prediction of in vivo toxicity. In this study, we investigated whether a hepatic in vitro system with improved metabolic competence enhance...

Background: Wound healing is one of the main problems faced by medical scientists. Nowadays, herbal compounds are used to accelerate the repairing process. Coumarin is a plant compound with anti-inflammatory and anti-oxidant effects. In the present study, the benefits of using coumarin in accelerating wound healing were investigated in mice.Methods: Sixty...

Coumarin-PVA is deposited onto p-Si wafers using the spin coating technique. I examined fundamental electrical variables of Al/CoumarinPVA/p-Si type Schottky barrier diodes (SBDs), by utilizing capacitance/voltage(C-V) and conductance/voltage (G-V) measurements at different frequencies varied from 10kHz to1MHz. have thoroughly explored how CoumarinPVA interlayer, series resistance (Rs) surfac...

The title compound, C21H14N2O2, was prepared by Pictet-Spengler cyclization of tryptamine and 4-formyl coumarin. In the mol-ecule, the dihedral angle between the mean planes of the coumarin and β-carboline ring systems is 63.8 (2)°. In the crystal, mol-ecules are linked via N-H⋯N hydrogen bonds, forming chains along the b-axis direction. Within the chains, there are a number of offset π-π inter...

In the title compound, C(26)H(26)N(2)O(2)S, the dihedral angle between the benzothia-zole and coumarin rings is 8.34 (7)°, indicating that the overall benzothia-zole substituent is almost coplanar with the coumarin rings. An intra-molecular S⋯O [2.813 (1) Å] contact may help to stabilize the mol-ecular conformation. In the crystal structure, π-π stacking inter-actions [centroid-centroid distanc...

In the title compound, 6-benz-yloxy-2H-1-benzopyran-2-one, C(16)H(12)O(3), the coumarin unit and benzyl plane in the mol-ecule are perpendicular to each other [86.92 (7)°]. The crystal packing is stabilized by π-π stacking inter-actions, with an inter-planar separation between inversion-related coumarin units of 3.618 (3) Å. The crystal structure shows inter-molecular C-H⋯O hydrogen bonding bet...

The effect of adding different volume coumarin dye (5, 15, 25 and 35) ml on optical properties Poly (Methyl Meth Acrylate) was studied. Films pure PMMA with were prepared using the casting technique. Transmission absorption films measured by UV-VIS spectrometer technique type (100 Conc), in order to assess transmission which found an indirect transition. An energy gap is (4.95e v) after (25, ml...

Coumarin is a constituent of many plants. It has found use in industry mainly due to its strong fragrant odour. Coumarin has been used in the treatment of a range of ailments such as cancer, burns, brucellosis and rheumatic disease [l]. The most commonly used quantitative method for coumarin analysis in biological samples is high per formance liquid chromatography (HPLC). However, this method r...

In the fresh tissues of Prunus mahaleb L., three classes of phenolics were characterised: phenolic acid derivatives (main compound being o-coumaric acid glucoside), quercetin glycosides, and anthocyanins (cyanidin 3,5-diglucoside, cyanidin 3-sambubioside, cyanidin 3-xylosyl-rutinoside and cyanidin 3-rutinoside). Coumarin was also identified. The kernels showed a high content of coumarin (0.87 m...

The formation of soluble 1:2 complexes within hydrophilic γ-cyclodextrin (γ-CD) thioethers allows to perform photodimerizations of aromatic guests under controlled, homogenous reaction conditions. The quantum yields for unsubstituted anthracene, acenaphthylene, and coumarin complexed in these γ-CD thioethers were found to be up to 10 times higher than in the non-complexed state. The configurati...