BACKGROUND Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women. OBJECTIVE The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD. MATERIALS AND METHODS Fifty one participants with do...

Methods: The design was a double-blind, placebo-controlled, randomized, multicenter study. 120 patients were included and tested as devised by Steiner. Primary variables were Premenstrual Tension Syndrome self-rating (PMTS-S) and Premenstrual Tension Syndrome observer-rating (PMTS-O). Secondary variables were PMS symptoms evaluated on visual analogue (VAS) scales. Femal tablets 160 mg (twice da...

Outcomes assessed in the review The presence or severity of PMS, evaluated through the use of daily prospective self-administered questionnaires (e.g. Moos Menstrual Distress Questionnaire, Calendar of Premenstrual Experiences, and the Premenstrual Assessment Form), daily visual analogue scales, global assignment after each cycle, or one-time assessment. Interventions were recorded as having po...

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are well-documented disorders causing significant morbidity in the female population. Treatments prescribed do not necessarily reflect proven clinical effectiveness. A recent systematic review from the Exeter Department of Complementary Medicine failed to endorse complementary therapies as a whole for treatment of PMS. Howev...

This double-blind, randomized, crossover study compared the efficacy and safety of danazol (100 mg twice daily) with matching placebo in the treatment of severe premenstrual syndrome. Nineteen patients were randomly allocated to receive danazol for 3 months followed by placebo, and 18 to receive treatment in the reverse order. Assessments of overall condition showed improvement to be statistica...

Contradictory findings show both positive and negative effect of progesterone on the premenstrual mood changes in women. Here we present the study investigating this relationship on the large sample of premenstrual women. 122 healthy, reproductive age women collected daily morning saliva samples and recorded intensity scores for the mood symptoms: irritability, anger, sadness, tearfulness, inso...

Background. Cyclic mastalgia (CM) is premenstrual bilateral and diffuse breast pain that presents cyclically affects women in their reproductive years. It may associate with latent hyperprolactinemia due to the insufficient inhibitory effect of dopamine on pituitary gland. Vitex agnus-castus (VAC) known for its dopaminergic activity possible actions CM hyperprolactinemia. However, treatment VAC...

The incidence of premenstrual syndrome is high. Premenstrual sufferers feel disturbed with the symptoms. One these symptoms stress. Stress can reduced by progressive muscle relaxation and Mozart's music therapy. purpose study was to determine effectiveness Music therapy on stress syndrome.This used quasy experiment nonquivalent control group design. population 89 midwifery students Health Polyt...

Premenstrual syndrome (PMS) refers to a wide range of symptoms that commonly effect women one to two weeks before their period (menstruation) begins. The specific causes of PMS are unknown, but fluctuating hormone levels during the menstrual cycle appear to play an important role. PMS can lead to both physical and mental complications; anxiety, depression, mood swings, irritability, insomnia, m...