FAM is a developmentally regulated substrate-specific deubiquitylating enzyme. It binds the cell adhesion and signalling molecules beta-catenin and AF-6 in vitro, and stabilises both in mammalian cell culture. To determine if FAM is required at the earliest stages of mouse development we examined its expression and function in preimplantation mouse embryos. FAM is expressed at all stages of pre...

Background: Enzymatic and histological change in the testicular cells of rats treated orally, intraperitoneally and intradermally for 45 days with Gibberellic acid (GBA) in independent studies is reported. This study was conducted to evaluate in vitro fertilization (IVF) rate and preimplantation embryonic development in GBA treated adult male rats. Materials and Methods: Thirty six adult male W...

Author argues the preimplantation genetic diagnosis is ethically acceptable for currently intended uses, but a variety of ethical and practical issues will arise with further development of this technology.

Preimplantation development of the mammalian embryo consists of stages that include formation of the <span style="font-variant: normal; font-style: normal; font-family: ArialM...

Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this s...

OBJECTIVE To investigate lipopolysaccharide (LPS)-induced DNA damage in preimplanting embryonic and uterine cells during preimplantation period of pregnancy that may ultimately inhibit the process of implantation in mouse. DESIGN Animal study. SETTING Academic research environment. ANIMAL(S) Sixty four Park strain female mice. INTERVENTION(S) The "minimum dose" (MD) of LPS was injected ...

OBJECTIVE To report the outcomes of more than 100 cycles of preimplantation genetic diagnosis for monogenetic diseases. DESIGN Case series. SETTING Tertiary assisted reproductive centre in Hong Kong, where patients needed to pay for the cost of preimplantation genetic diagnosis on top of standard in-vitro fertilisation charges. PATIENTS Patients undergoing preimplantation genetic diagnosi...