Motivation Identification of rodent carcinogens is an important task in risk assessment of chemicals. SAR methods were proposed to reduce the number of animal experiments. Most of these methods ignore information about organ-specificity of tumorigenesis. Our study was aimed at the creation of classification models and a freely available online service for prediction of rodent carcinogens consid...

Electroencephalographic (EEG) recordings are thought to reflect the network-wide operations of canonical neural computations, making them a uniquely insightful measure of brain function. As evidence of these virtues, numerous candidate biomarkers of different psychiatric and neurological diseases have been advanced. Presumably, we would only need to apply powerful machine-learning methods to va...

This research aims to describe the profile of vital lung capacity professional divers in Ujung Kulon National Park. type is descriptive with a cross sectional approach. The subjects this study all population Park, totaling 24 people varying age categories, ranging from 20-29 years, 30-39 40-49 50-59 years. data collection techniques were carried out by interviewing, questionnaire, and tests usi...

Though intravenous (IV) Magnesium Sulphate (MgS04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. The aim of this investigation was to evaluate the role of IV MgSO4 when used as an adjunct to standard therapy of severe exacerbations of ...

Osteoporosis is an aging process of skeletal tissues with characteristics of reductions in bone mass and microarchitectural deterioration of bone tissue. The present study aimed to investigate the effects of glucocorticoid‑induced osteoporosis on osteoblasts and to examine the roles of β‑ecdysterone (β‑Ecd) involved. In the present study, an in vivo model of osteoporosis was established through...

BACKGROUND Acute rejection episodes (ARE) of kidney transplants are considered as risk factor in the development of chronic rejection. In adult renal transplantation (RTx), ARE have been significantly reduced by mycophenolate mofetil (MMF) in combination with cyclosporin (CyA) and steroids (Pred). Reports of pediatric RTx on a maintenance immunosuppression with MMF are restricted to patients (P...

BACKGROUND Pulmonary alveolar proteinosis (PAP) is a rare lung disease, the most common type of which is autoimmune PAP. The gold standard therapy for PAP is whole lung lavage (WLL). Few studies have reported the optimal technique with which to evaluate the response to WLL. In this study, we aimed to identify parameters with which to assess the need for repeat WLL during a long-term 8-year foll...

Alterations in hemostasis leading to symptomatic thromboembolism have been observed in patients with acute lymphoblastic leukemia (ALL) receiving Escherichia coli asparaginase (CASP) combined with steroids. Moreover, hereditary prothrombotic risk factors are associated with an increased risk for venous thromboembolism in pediatric ALL patients treated according to the BFM 90/95 protocols (inclu...

ion, and substitution is simple: fun replace_term (u,new) t = if t=u then new else case t of Fun(a,ts) => Fun(a, map (replace_term(u,new)) ts) | _ => t; fun abstract t = let fun abs i (Pred(a,ts)) = Pred(a, map (replace_term (t, Bound i)) ts) | abs i (Conn(b,As)) = Conn(b, map (abs i) As) | abs i (Quant(q,b,A)) = Quant(q, b, abs (i+1) A) in abs 0 end; fun subst_bound t = let fun subst i (Pred(a...

This study is the first to report approximations of energy requirements for male and female breast-fed and formula-fed infants based on individual estimates of total daily energy expenditure (TDEE) and energy deposition derived from total body fat (TBF) and fat-free mass (FFM) gain as determined by total-body electrical conductivity. In 46 healthy, full-term infants the effect of > or = 4 mo of...