Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O-(2)). NO synthase (NOS) has been shown to participate in PQ-induced lung injury. Current theory holds that NO reacts with O-(2) generated by PQ to produce the toxin peroxynitrite. We asked whether NOS might alternatively func...

Pulmonary fibrosis (PF) is one of the most prevalent causes of death following paraquat (PQ) poisoning. As demonstrated in previous studies by the present authors, epithelial-to-mesenchymal transition (EMT) is associated with PQ-induced PF. In addition, hypoxia-inducible factor-1α (HIF-1α) and lysyl oxidase (LOX) promote EMT following PQ poisoning. However, the association between HIF-1α- and L...

Mortality in patients with paraquat (PQ) poisoning is related to plasma PQ levels. Concentrations lower than 5,000 ng/mL are considered critical but curable. This study assessed the effects of hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the survival of PQ-poisoned patients with plasma PQ levels below 5,000ng/mL. We analyzed the records of 164 patients with PQ poisoning...

To investigate the effects of reactive oxygen species (ROS) on tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) plasma levels, and their possible implications on clinical outcome, we measured tPA and PAI-1 levels in 101 patients with acute paraquat (PQ) intoxication. The control group consisted of patients who ingested non-PQ pesticides during the same period. tP...

Dual Two-Level Inverter is an emerging Multilevel Inverter Topology which is implemented by cascading two standard TwoLevel inverters with a six-wire open-end load in between them. Space Vector PWM Technique is implemented considering its various advantages and is selected as a good performing control strategy to control the Dual-inverter. Dual Two-Level Inverter produces space vector locations...

This research proposes the use of hardware emulation for inverter plants for the first time. This results in a new low cost, safe and robust solution for teaching control strategies for power electronics inverter circuits, composed of a digital controller (DSP or FPGA) connected to the inverter “hardware emulation circuit”. The inverter dynamical behavior is emulated by cheap operational amplif...

In this paper, the main Power Quality (PQ) problems are presented with their associated causes and consequences. The economic impacts associated with PQ are characterized. Finally, some solutions to mitigate the PQ problems are presented.

Loading erythrocytes with Primaquine (PQ) is advantageous. However, PQ produces damage to erythrocytes through free radicals production. Statins have antioxidant action and are involved in protective effect against situation of oxidative stress. Thus the protective effect of pravastatin (PS) against PQ induced oxidative damage to human erythrocytes was investigated in the current studies upon l...

Experimental evidence supporting 1,1'-dimethyl-4,4'-bipyridinium [paraquat (PQ)] as a risk factor for Parkinson's disease (PD) is equivocal. Other agricultural chemicals, including dithiocarbamate fungicides such as manganese ethylenebisdithiocarbamate [maneb (MB)], are widely used in the same geographical regions as paraquat and also impact dopamine systems, suggesting that mixtures may be mor...

─ the paper describes the operational principle of flying capacitor and modular multilevel inverters. The detailed discussions of dc link capacitors voltage balancing methods for both inverters are given in order to enable fair comparison. The causes of dc link capacitors voltage imbalance in flying capacitor multilevel inverter with more than three levels are highlighted. Computer simulation i...