To conduct ex-situ creole pig conservation programs, it is essential to determine which breeding animals will be used, preferentially those with a more significant Iberian genetic component preserve their origin. This study used Yucatan black hairless pigs (YBHP) subpopulation estimate its diversity and population structure. One hundred four adult were selected for the absence of hair, skin (wi...

Abstract Filbertone, the principal flavor compound of hazelnuts, is known to have preventive effects against hypothalamic inflammation, obesity and adipocity in vitro vivo. However, effect filbertone skeletal muscle remains unknown. In present study, we determined mice fed a high-fat diet (HFD). To identify underlying molecular cellular processes filbertone, performed whole transcriptome sequen...

OBJECTIVE The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glucose-induced insulin secretion (GIIS) in pancreatic β-cells. Genetically engineered Ffar1-knockout/congenic mice univocally displayed impaired fatty acid-mediated insulin secretion, but in vivo experiments delivered controversial results regarding the function of FFAR1 in glucose homeostasis and l...

Drug exposures can lead to an increased expression of specific cytochrome P-450 proteins (P-450s) as well as of phase II drug-metabolizing enzymes that can greatly augment the metabolism and clearance of therapeutic drugs. Animal models have been used to estimate the potential of drugs to induce P-450s in humans, but differences in drug response among species hinder reliable extrapolation of ob...

AimsTo evaluate the effects of fetal glucose infusion in late gestation on mRNA expression and protein abundance molecules involved regulation cardiac growth metabolism.Main methodsEither saline or was infused into sheep from 130 to 140 days (d) (term, 150 d). At d gestation, left ventricle tissue samples were collected. Quantitative real-time RT-PCR Western blot used determine key signalling w...

Division of Molecular and Cellular Biology, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, and Department of Immunology, University of Toronto, Toronto, ON, Canada; Transplant Research Division, Toronto General Hospital, Toronto, ON, Canada; Ontario Cancer Institute/Princess Margaret Hospital, Toronto, ON, Canada; Department of Medicine, University of Toro...

Natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists are found in food and may be important for health through their anti-inflammatory properties. Curcumin (Cur) is a bright yellow spice, derived from the rhizome of Curcuma longa Linn. It has been shown to have many biological properties that appear to operate through diverse mechanisms. Some of these potentially beneficial ef...