I t is well known that postchallenge and postprandial hyperglycemia are related to the progression of diabetic macroangiopathy (1–6). However, there is little information regarding the association between diabetic microangiopathy and postprandial hyperglycemia in human subjects. In this study, we performed a follow-up study to elucidate the relationship between diabetic retinopathy and postpran...

Postprandial hyperglycemia induces prolonged hyperinsulinemia, which is a risk factor for type 2 diabetes mellitus. Foods with a low glycemic index blunt the rapid rise in postprandial plasma glucose and insulin levels. We herein investigated the effects of a novel, palatinose-based liquid diet (Inslow, Meiji Dairy Products, Tokyo, Japan) on postprandial plasma glucose and insulin levels and on...

Diabetic Nephropathy (DN) is the most common complication of Type 2 Diabetes Mellitus (T2DM), leading to highest mortality rate DM complications. However, its etiology still questionable. Hyperglycemia, hypertension, and particular genetic susceptibility are associated with DN. Not all patients uncontrolled hyperglycemia suffer Thus, may be a risk factor for The variant angiotensinogen rs699 kn...

371 Recent studies have provided important insights into the complex relationships between upper gastrointestinal function and glycemic control in diabetes; it is now recognized that postprandial blood glucose concentrations are both a determinant of, as well as determined by, the delivery of nutrients from the stomach into the small intestine. Furthermore, the prevalence of upper gastrointesti...

INTRODUCTION In patients with type 2 diabetes mellitus (T2DM) with uncontrolled glycemia despite ongoing upward titration of basal insulin, targeting postprandial hyperglycemia may be required. Nevertheless, the point at which basal insulin is fully optimized and postprandial glucose (PPG) should be targeted with additional treatment remains unclear. We report here on the BeAM value (difference...

Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats grouped into 3 (n=15/group): Group 1- Control, 2- Diabetes, 3- Postprandial hyperglycemia. The 15 per group sub-grouped of 5 each. Each sub-group determined gastric emptying...

BACKGROUND It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA) metabolism may participate in the development of tissue lipotoxicity and type 2 diabetes (T2D). We previously found that non-diabetic offspring of two parents with T2D display increased plasma NEFA appearance and oxidation rates during intravenous administration of a fat emulsion. However, it is cu...

The International Diabetes Federation (IDF) recently published guidelines for the management of postmeal hyperglycemia. These guidelines were established in view of the risk of postmeal hyperglycemia for vascular events. Because of the rising incidence and prevalence of diabetes and its complications, the IDF took action to state useful strategies for the treatment of diabetes, focusing on the ...

The control of blood glucose levels is critical in the treatment of diabetes mellitus. α-Glucosidase inhibitors are of great importance in reducing hyperglycemia, and plants have provided many of these agents. The present study aimed at investigating the effect of two stilbenes, lonchocarpene and 3,5-dimethoxy-4'-O-prenyl-trans-stilbene (DPS), isolated from the Amazonian plant Deguelia rufescen...

OBJECTIVE The aim of the study was to determine whether the loss of fasting and postprandial glycemic control occurs in parallel or sequentially in the evolution of type 2 diabetes. RESEARCH DESIGN AND METHODS In 130 type 2 diabetic patients, 24-h glucose profiles were obtained using a continuous glucose monitoring system. The individuals with type 2 diabetes were divided into five groups acc...