post-traumatic stress disorder (ptsd) is the one of the main disorders arising from disastrous experiences. road accidents are common reasons for mental disorders which are associated with trauma. with regard to the prevalence and effects of ptsd, treatment of these disorders is very important. the aim of the present study is to determine the efficacy of cognitive-behavioral therapy in reducing...

the most important characteristics of ptsd, as an anxiety disorder, are memory disorders and hippocampus is one of the essential structures which plays a critical role in ptsd memory disorders. traumatic events cause apoptosis and alter the expression of neurotrophic factors in hippocampus. the aim of this study is to evaluate the effects of β-estradiol on behavioral responses in ptsd and to st...

post-traumatic stress disorder (ptsd) is an anxiety disorder that can typically occur after traumatic events in which the individual felt sever helplessness or horror. ptsd has a lifetime prevalence of 5–8% and women show higher prevalence than in compared with men. neuroinflammation is associated to anxiety and related disorders such as ptsd. it is an early, specialized immune reaction fallowi...

objective: several studies have shown that following disasters, major depressive disorder is the most common psychiatric disorder that occurs with posttraumatic stress disorder (ptsd). comorbidity of anxiety symptoms have also been shown. the objective of this study was to show the comorbidity of depressive and anxiety symptoms in adolescent survivors of bam earthquake. method: in a case–contro...

objective: reports of the prevalence of ptsd has been variable between 28-70% after the earthquake disaster in the city of bam, among children. several studies in adults have shown a high comorbidity of anxiety disorders as well. in this study we evaluated the frequency of ptsd and anxiety symptoms among adolescents in the period of 7-9 months after a large scale disaster (bam earthquake). meth...

the growing trend of disasters in world and iran, expanded range of different psychological consequences of disasters and according to them parallel physical consequences. post-traumatic stress disorder may be considered the most common psychological consequences of disasters. in the absence of prevention and treatment, it can affect a person's quality of life and normal functioning of the...

Background: Apolipoprotein E (APOE) and elastin (ELN) are plausible candidate genes involved in the pathogenesis of stroke. We tested for association of variants in APOE and ELN with subarachnoid hemorrhage (SAH) in a population-based study. We genotyped 12 single nucleotide polymorphisms (SNPs) on APOE and 10 SNPs on ELN in a sample of 309 Caucasian individuals, of whom 107 are SAH cases and 2...

Toll-like receptor 4 (TLR4) has been proven to play a critical role in neuroinflammation and to represent an important therapeutic target following subarachnoid hemorrhage (SAH). Resveratrol (RSV), a natural occurring polyphenolic compound, has a powerful anti-inflammatory property. However, the underlying molecular mechanisms of RSV in protecting against early brain injury (EBI) after SAH rema...

BACKGROUND AND PURPOSE Vasospasm-induced delayed cerebral ischemia remains a major source of morbidity in patients with aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that activating innate neurovascular protective mechanisms by preconditioning (PC) may represent a novel therapeutic approach against SAH-induced vasospasm and neurological deficits and, secondarily, that the neurovascu...