The mechanism of the elevation of intracellular glutathione induced by low-dose gamma-rays was examined in RAW 264.7 cells. The expression of mRNA for gamma-glutamylcysteine synthetase (gamma-GCS) increased soon after gamma-ray (0.5 Gy) irradiation, and peaked between 3 h and 6 h post-irradiation. A dose of 0.25 to 0.5 Gy was optimum for induction of gamma-GCS mRNA expression at 3 h post-irradi...

The use of commercial window glass as possible high dose routine dosimeter has been investigated. Glass samples have been irradiated with doses in the range of 1–50 kGy using 60Co γ source, 4 MeV and 12 MeV electron accelerators. The samples were given a post irradiation thermal treatment (150 oC for 20 min) in order to improve the post irradiation stability of the measured specific optical abs...

Our work analyses the effects of radiotherapy in cervical carcinoma by computerized morphometry techniques that evaluate the morphologic changes in the specimens taken from pre and post-irradiation biopsies of 8 cases. These cases were diagnosed as squamous cell carcinoma, undifferentiated (1 case), moderately (5 cases) and well differentiated (2 cases). For each case, 40 relevant microscopic f...

This study was aimed to evaluate the possible protective effects of ursolic acid (UA) against gamma radiation induced damage both in vitro as well as in vivo. It was observed that the exposure to gamma radiation dose- and time-dependently caused a significant decrease in the cell viability, while the treatment of UA attenuated this cytotoxicity. The production of free radicals including reactiv...