introduction: beta thalassemias are a heterogenous group of autosomal recessive disorders, characterized by reduced or absent production of the b-globin chain by the affected allele. transplantation of allogenic hematopoietic stem cells (hsc) is a curative approach but this therapeutic option is not available to the majority of patients. transplantation of genetically corrected autologous hsc i...

Vascular smooth muscle cells (SMCs) have been broadly used for constructing tissue-engineered blood vessels. However, the availability of mature SMCs from donors or patients is very limited. Derivation of SMCs by differentiating embryonic stem cells (ESCs) has been reported, but not widely utilized in vascular tissue engineering due to low induction efficiency and, hence, low SMC purity. To add...

despite the importance of forage quality to animal performance, the quality of barley as a feed and forage crop has not been taken into consideration as a selection criterion in its breeding programs. in order to map the genomic regions affecting barley forage quality, two experiments were conducted while employing 72 doubled haploid lines and their two parents (‘steptoe’ and ‘morex’), at the r...

Growth hormone (GH) is the most important hormone that controls somatic cell growth and syntheses of protein, fat, and carbohydrates. This study was conducted to identify gene polymorphism of GH-1 using PCR -single strand conformation polymorphism (SSCP) technique and its association with growth traits including condition factor (CF), body weight (BW) and total length (TL) in common carp (Cypr...

Marker-assisted background selection is a powerful molecular tool that can enhance breeding efficiency through the analysis of large number markers representing entire genomic for precise selection. In present study, transcriptomes 38 cucumber inbred lines with diverse traits were sequenced single nucleotide polymorphism (SNP) mining practical application to commercial breeding. A total 62,378 ...