OBJECTIVES The aim of this study was to compare the relative efficacy of continuous positive airway pressure (CPAP) and positional treatment in the management of positional obstructive sleep apnea (OSA), using objective outcome measures. DESIGN A prospective, randomized, single blind crossover comparison of CPAP and positional treatment for 2 weeks each. SETTING A university teaching hospit...

We describe a human cDNA encoding 1-kinase activity that inactivates Ins(3,4,5,6)P(4), an inhibitor of chloride-channel conductance that regulates epithelial salt and fluid secretion, as well as membrane excitability. Unexpectedly, we further discovered that this enzyme has alternative positional specificity (5/6-kinase activity) towards a different substrate, namely Ins(1,3,4)P(3). Kinetic dat...

Dizziness and vertigo are some of the more frequently encountered symptoms in neurology clinics. In turn, one of the most common causes of vertigo is benign paroxysmal positional vertigo (BPPV), accounting for a quarter of all patients with dizziness and vertigo. Reviewing the value of the positional manoeuvres available is relevant, particularly in the light of the efficient treatments availab...

Genetic linkage maps of molecular markers have facilitated the identification of quantitative trait loci (QTL) for economically important traits in a variety of cultured fish species (Tao and Boulding 2003, Cnaani et al. 2004, Reid et al. 2005). In rainbow trout, several QTLs have been identified for disease resistance (Palti et al. 1999, Ozaki et al. 2001), environmental stress tolerance (Danz...

BACKGROUND Although sources of positional error in geographic locations (e.g. geocoding error) used for describing and modeling spatial patterns are widely acknowledged, research on how such error impacts the statistical results has been limited. In this paper we explore techniques for quantifying the perturbability of spatial weights to different specifications of positional error. RESULTS W...

The management of IT carve-out projects is very challenging due to the strict time frame, the severe contractual penalties, the huge number of stakeholders and the various as well as unique IT tasks that have to be conducted. Up to now, there is no instrument for evaluating the readiness of the IT for a carve-out and also not for managing such a project. In order to address this, we develop a m...

Any public administration that produces translation data can be a provider of useful reusable data to meet its own translation needs and the ones of other public organizations and private companies that work with texts of the same domain. These data can also be crucial to produce domain-tuned Machine Translation systems. The organization's management of the translation process, the characterist...

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The recent release of CMMI V1.3 incorporates a number of changes to the model and framework; one of the more interesting is the decision to do away with Capability Levels 4 and 5 in the Continuous Representation, while retaining the high levels of Organizational Maturity. This paper examines some of the issues that may have driven this decision, and explores the opportunity provided for greater...