Non-cirrhotic intrahepatic portal hypertension (NCIPH), also called idiopathic or benign, may lead to life-threatening complications. It is a rare indication for orthotopic liver transplantation (OLTx), although it may remain underdiagnosed. Overt symptoms of portal hy-pertension, predominantly variceal bleedings, misleadingly suggest that these patients are cirrhotic. Non-cir-rhotic intrahepat...

Portal hypertension is commonly due to obstruction to portal blood flow either within the liver as in cirrhosis, or within the portal vein, as from thrombosis. In recent years, however, reports have multiplied of portal hypertension in the absence of both intrahepatic and extrahepatic obstruction (Rousselot, 1940; Whipple, 1945; Hallenbeck and Shocket, 1957; Tisdale, Klatstin, and Glenn, 1959; ...

While increased resistance to portal blood flow is a central feature of portal hypertension, the varied clinical presentations of this syndrome and their relation to the underlying divergent splanchnic hemodynamic patterns remain puzzling. Some patients present with massive ascites, repeated hemorrhage from ruptured esopha-geal varcies, and severe hypersplenism, whereas others with equivalent o...

Twenty-eight patients with hepatosplenic schistosomiasis and portal hypertension were studied. The transumbilical portal pressure, transsplenic portal pressure, and thoracic duct occluded pressure were measured simultaneously and thoracic duct lymph flow estimated. Changes in the splanchnic vasculature were studied radiologically barium swallow, splenoportography, and umbilical portography. The...

hepatoportal sclerosis or idiopathic portal hypertension has a worldwide distribution with prevalence in developing and temperate countries. of 64 patients with this disease seen during a twelve year period, 36 underwent splenectomy or a shunt procedure. the indications for surgical intervention were severe hypersplenism and persistent left upper abdominal pain andlorhistory of frequent episode...

BACKGROUND Recent studies have shown the presence of vascular endothelial growth factor (VEGF)-dependent splanchnic angiogenesis in experimental models of portal hypertension, and the role of such neovascularisation on the development of both portosystemic collaterals and hyperdynamic splanchnic circulation. However, the mechanisms modulating angiogenesis in portal hypertension are unknown. Exp...

In this study we have examined blood flow in a model of the portal vein with and without obstructions to simulate conditions, which are common in liver diseases. We evaluated the impact of both conditions on the flow behaviour and found significant differences in the two models. Blockages, even when the flow conditions did not change, had an impact on the velocity magnitude, pressure, strain ra...

We report the cases of two renal transplant recipients suffering from idopathic portal hypertension, a condition characterised by increased portal venous pressure in the absence of both histological lesion of the liver and obstruction of the portal vein. In these two patients, perisnusoidal fibrosis, invisible by light microscopy, was demonstrated by electron microscopy; it is suggested that pa...