BACKGROUND Apoptosis is important for maintenance of tissue homeostasis and often dysregulated in cutaneous neoplasms. The apoptosis inhibitor survivin is expressed in melanoma and non-melanoma skin cancers and benign keratinocytic lesions. Its expression has not been studied in melanocytic nevi. OBJECTIVE We determined the expression pattern of survivin in benign melanocytic nevi in comparis...

Inflammatory linear verrucous epidermal nevus and linear psoriasis are sometimes hard to differentiate clinically and pathologically. Although immunohistochemical expression of keratin 10 (K10), K16, Ki-67, and involucrin may be useful for differentiating both entities, these results have been reported in only a few cases. We collected data from 8 patients with inflammatory linear verrucous epi...

IMPORTANCE Recognition of posterior scleral bowing with choroidal nevus is essential to avoid an underestimation of tumor thickness. OBJECTIVE To describe a particular observation of posterior scleral bowing associated with choroidal nevus on enhanced-depth imaging (EDI) optical coherence tomography (OCT). DESIGN, SETTING, AND PARTICIPANTS Retrospective observational case series at a referr...

Nevus of Ota is a macular discoloration the face which most commonly found in Japanese and females are more affected than males. It first described by Tanino 1939, involves skin along distribution second division trigeminal nerve. Involvement palatal mucosa occurs rarely nevus Ota, it usually blends with oral typically irregular, undefined often present as mottled patch. We describe here case i...

Nevus lipomatosus superficialis is a rare type of connective tissue nevus. Cylindroma is a benign skin appendage tumor with a predilection for the scalp of older females. We describe the case of a 56-year-old woman with a scalp lesion demonstrating histopathologic features consistent with benign cylindroma arising within a nevus lipomatosus superficialis. To our knowledge, this lesion has not b...

INTRODUCTION Prostatic blue nevus was first described as a benign lesion of uncertain and controversial histogenesis by Nogogosyan in 1963. Currently, 30 cases have been reported in the world literature. CASE PRESENTATION A 63-year-old Hispanic man presented with prostatism of several months' evolution. Histopathological examination revealed a blue nevus associated with nodular hyperplasia an...

The external auditory canal is an uncommon location for the nevi that are common benign tumors of the skin. A papillomatous lesion was detected in the external auditory canal of the patient who was on follow-up for acute otitis externa. The lesion which resembled a nevus was excised and was diagnosed as an intradermal nevus in pathological examination. The clinical and pathological picture of t...

Vitiligo, an autoimmune disorder, is known to co-localize with other immunological disorders like lichen planus and psoriasis. However, there are no reports regarding the co-localization of an autoimmune disorder (vitiligo) and a developmental disorder (verrucous epidermal nevus). We hereby present a 10-month-old infant who was visited for white patches on the right buttock and adjoining antero...

When dermatologists see acquired and wellcircumscribed pigmented macules on the palm, dorsal hand or forearm of the elderly, they tend to consider blue nevus, hematoma, nevus cell nevus and malignant melanoma as differential diagnoses [1]. We herein described the very rare case of localized lentigo accompanied by post-inflammatory pigmentation in a patient who has been treated for palmoplanter ...

Malignant melanoma (MM) is a type of malignant tumor, which originates from neural crest melanocytes. MM progresses rapidly and results in a high mortality rate. The present study aims to investigate the expression of microphthalmia transcription factor (MITF), the S100 protein, and HMB-45 in MM and pigmented nevi. A total of 32 MM samples (including three skin metastasis, three lymph node meta...