L-type calcium channels are composed of a pore, 1c (CaV1.2), and accessory and 2 subunits. The -subunit core structure was recently resolved at high resolution, providing important information on many functional aspects of channel modulation. In this study we reveal differential novel effects of five 2-subunits isoforms expressed in human heart ( 2a-e) on the single L-type calcium channel curre...

The phase behavior of short-chain fluids in slit pores is investigated by using a nonlocal-density-functional theory that takes into account the effects of segment size, chain connectivity, and van der Waals attractions explicitly. The layering and capillary condensation/evaporation transitions are examined at different chain length, temperature, pore width, and surface energy. It is found that...

We use Metropolis Monte Carlo and umbrella sampling to calculate the free energies of interaction of two methane molecules and their charged derivatives in cylindrical water-filled pores. Confinement strongly alters the interactions between the nonpolar solutes and completely eliminates the solvent separated minimum (SSM) that is seen in bulk water. The free energy profiles show that the methan...

The adsorption of a metallo-supramolecular coordination polymer (Fe-MEPE) in the cylindrical pores of SBA-15 silica with pure and carboxylic acid (CA) carrying pore walls has been studied. Fe-MEPE is an intrinsically stiff polycation formed by complexation of Fe(II)-acetate with an uncharged ditopic bis-terpyridine ligand. The adsorption affinity and kinetics of the Fe-MEPE chains is strongly e...

We present a framework for the application of multiscale science and technology to Enhanced Oil Recovery [EOR] by propagating physical models for wetting and flow from the molecular scale to the scale of pore networks in reservoir rock. The framework contains dedicated, computational and experimental platforms for performing calibrations at critical length scales. The appoach enables us to scie...

1. Introduction The condensation of liquids from the gas phase and the pore emptying mechanism in mesoporous frameworks (pore size 2 – 50 nm) represents an important scientific issue owing both to the significant industrial relevance (catalysis, separation process, etc.), but also to its importance for the fundamental understanding of the behavior of fluids in confined space. In general, the fi...

Tpr is a 270-kD coiled-coil protein localized to intranuclear filaments of the nuclear pore complex (NPC). The mechanism by which Tpr contributes to the structure and function of the nuclear pore is currently unknown. To gain insight into Tpr function, we expressed the full-length protein and several subdomains in mammalian cell lines and examined their effects on nuclear pore function. Through...

We consider the Poisson-Boltzmann equation in a periodic cell, representative of a porous medium. It is a model for the electrostatic distribution of N chemical species diluted in a liquid at rest, occupying the pore space with charged solid boundaries. We study the asymptotic behavior of its solution depending on a parameter β which is the square of the ratio between a characteristic pore leng...

Recent experimental studies show that electrokinetic phenomena such as electroosmosis and electrophoresis can be used to separate nanoparticles on the basis of their size and charge using nanopore-based devices. However, the efficient separation through a nanopore depends on a number of factors such as externally applied voltage, size and charge density of particle, size and charge density of m...