Endometriosis is considered as a benign aseptic inflammatory disease, characterised by the presence of ectopic endometrium-like tissue. Its symptoms (mostly pain and infertility) are reported as constant stressors. Corticotropin releasing hormone (CRH) and urocortin (UCN) are neuropeptides, strongly related to stress and inflammation. The effects of CRH and UCN are mediated through CRHR1 and CR...

Infertility is one of the most prevalent chronic health disorders involving young adults. defined as failure to establish a clinical pregnancy after 12 months regular and unprotected sexual intercourse. Endometrium important factors for successful pregnancy. Endometrial thickness marker endometrial receptivity prognostic factor A thin endometrium generally less than 7 mm. Thin adversely affect ...

AIM To study the transcriptome profiles in the blood of recurrent implantation failure (RIF), recurrent miscarriage (RM) and fertile women during the window of implantation, and further analysis the correlation of transcriptome profiles between blood and endometrium. METHODS This is an observational prospective study. In total 9 subjects were recruited, 3 RIF, 3 RM, and 3 controls. Paired sam...

The endometrium is one of the most dynamic structures in the human body characterised hy a complete life cycle within a short span of time. Although there can be no doubt about the role of estrogen in promoting endometrial growth and progesterone in influencing the differentiation, yet little is known of the mechanisms by which such changes are accomplished. Behind the constantly changing struc...

BACKGROUNDS the prevalence of infertility is up to 10 to 15 % which 9 to 24 % of them are Poor Ovarian Responders (POR). This study was designed to compare two methods of GnRH Agonist Microdose Flareup (MF) and GnRH Antagonist/Letrozole (AL) in treatment of these patients. METHODS & MATERIALS this randomized clinical trial study consisted of 123 patients. In the first step of treatment in bot...

On a woman with severe intrauterine adhesions, hysteroscopy followed by cyclical hormone replacement therapy was tried for 5 months, for development of the endometrium. When this failed, autologous stem cells were tried as an alternative therapy. Adult autologous bone marrow mesenchymal stem cells isolated from patient’s own bone marrow and were cultured and placed in the endometrial cavity und...

PROBLEM There is little information regarding the impact of the intrauterine device on immune parameters of the upper female reproductive tract related to risk of HIV acquisition. METHOD OF STUDY We collected cervical and endometrial samples from women using the hormonal intrauterine device to study its effects on endocervical cytokines/chemokine concentrations, phenotypic markers of T cells,...

Dysfunctional uterine bleeding is defined as pathological bleeding from uterus unexplained on basis of inflammation, neoplasia or pregnancy within the uterus. The present study was undertaken with the aim of studying the different histological patterns of endometrium in patients of DUB. This study includes 84 patients with clinically diagnosed DUB who had undergone either hysterectomy or D&C. S...

OBJECTIVE To determine if gray-scale ultrasound morphology in the presence or absence of intrauterine fluid and endometrial vascular morphology as assessed by color Doppler ultrasonography can discriminate between benign and malignant endometrium in women with postmenopausal bleeding. METHODS In a prospective study 95 consecutive women with postmenopausal bleeding and endometrial thickness > ...

p21-activated kinases (Paks) are serine/threonine protein kinases involved in biological events linked to malignant tumor progression. In this study, expression of Pak1, p-Pak2 Ser20, Pak4, pPak4 Ser474 in 21 normal endometrium, 16 hyperplastic endometrium without atypia, 17 atypical complex hyperplasia and 67 endometrial cancers was assessed by immunohistochemistry and correlated with clinicop...