background: arsenic as an environmental toxicant is able to induced oxidative stress. the present study aimed to evaluate of vitamin c supplementation on the paraoxonase1 (pon1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic. methods: the study was conducted in the faculty of veterinary medicine, tabriz islamic azad university, tabriz, iran in 2001...

BACKGROUND The hypothesis that paraoxonase (PON1) has a role in preventing atherosclerosis is based on experimental, transgenic, and case-control studies but has not previously been tested prospectively. METHODS AND RESULTS The Caerphilly Prospective Study is a cohort study of men aged 49 to 65 years observed for coronary heart disease (CHD) events (fatal and nonfatal myocardial infarction) o...

Pilocarpine has been widely used in ophthalmic preparations for the treatment of glaucoma and in oral preparations for the treatment of radiation-induced xerostomia and Sjögren syndrome. The major metabolic pathways of pilocarpine in human are hydrolysis and hydroxylation. It was found that CYP2A6 is responsible for the 3-hydroxylation, but the enzymes responsible for the hydrolysis have not be...

Inuit people living in Canada’s Nunavik region consume large doses of methylmercury through their traditional diet, mostly from sea mammal meat. A new study set out looking for evidence of links between these native communities’ exposure to the toxic metal and heart diseases [EHP 118(8):1077–1083; Ayotte et al.]. The results suggested an inhibitory effect of methylmercury on paraoxonase 1 (PON1...

Inuit people living in Canada’s Nunavik region consume large doses of methylmercury through their traditional diet, mostly from sea mammal meat. A new study set out looking for evidence of links between these native communities’ exposure to the toxic metal and heart diseases [EHP 119(8):1077–1083; Ayotte et al.]. The results suggested an inhibitory effect of methylmercury on paraoxonase 1 (PON1...

We evaluated the association of indices of paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participants were 491 adults (126 men) who were stratified by diabetes status and body mass index (BMI). Carotid intima-media thickness (CIMT) was used as a measure of subclinical CVD. Indices of PON1 and oxidative status were determi...

Relationships between hepatic antioxidant paraoxonase (PON1) activity, lipid peroxidation, and liver injury were investigated in rats with CCl(4)-induced cirrhosis. The study was performed in 60 CCl(4)-treated rats and 60 control animals receiving a standard diet or one supplemented with zinc. Subsets of 10 animals each were killed at weeks 1, 5, and 7 of the study. Results showed that PON1 sig...

Background: This study was conducted to evaluate the effects of feeding on biochemical parameters in terms metabolic profile female and male lambs Dorper Lacaune breeds at developmental stages from birth. Methods: A total 32 singleton newborn breed (n= 8 for each group; female) were used. The trial continued 5 nutritional periods 21-day after first two weeks (0-14 days) suckling period. determi...

Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially divided into two groups. Control (CON), which received a normal salt diet and dri...

BACKGROUND Paraoxonase-1 (PON1) is one of the HDL-associated proteins which contributes to the antioxidant properties of these lipoproteins. The aim of this pilot study was to evaluate the effect of the nutritional supplement ALAnerv® on serum PON1 activity in post-acute stroke patients undergoing rehabilitation. METHODS We enrolled 28 post-acute stroke patients and randomly divided them into...