In the crystal structure of the title compound, C(12)H(10)ClNO(2)S, the N-H bond is trans to one of the S=O bonds. The two aromatic rings form a dihedral angle of 65.4 (1)°, compared with a value of 49.1 (1)° in N-(2-chloro-phen-yl)-benzene-sulfonamide. The mol-ecules are connected by inter-molecular N-H⋯O hydrogen bonds into chains running along the b axis.

Cotrimoxazole inhibits dhfr and dhps and reportedly selects for drug resistance in pathogens. Here, Streptococcus mutans isolates were obtained from saliva of HIV/AIDS patients taking cotrimoxazole prophylaxis in Uganda. The isolates were tested for resistance to cotrimoxazole and their folP DNA (which encodes sulfonamide-targeted enzyme dhps) cloned in pUC19. A set of recombinant plasmids carr...

In the title compound, C(13)H(13)NO(2)S, the conformation of the N-H bond is anti to the ortho-methyl group on the aniline ring, in contrast to the syn conformation observed with respect to the ortho-chloro group in N-(2-chloro-phen-yl)benzene-sulfonamide. The dihedral angle between the two benzene rings is 61.5 (1)°. Mol-ecules are linked into chains running along the a axis by N-H⋯O hydrogen ...

The title mol-ecule, C(14)H(14)Cl(2)N(2)O(4)S(2), lies on an inversion center. The mol-ecule is twisted in the region of the sulfonamide group with a C-S-N-C torsion angle of -67.49 (16)°. In the crystal, mol-ecules are connected via inter-molecular N-H⋯O and weak C-H⋯O hydrogen bonds, forming layers parallel to (100).

biological effects extracorporeal shock wave lithotripsy (eswl) is not precisely known. we have evaluated two urinary enzymes activity n-acetyl-b-d-glucosamine (nag) and alanine amino peptidase (aap) before and after unilateral eswl as markers for renal parenchymal damage. forty eight patients with kidney stones (mean age 39) who had presented for the first time or at least one year after their...

Korach-André, M., Y. Burelle, F. Péronnet, D. Massicotte, C. Lavoie, and C. Hillaire-Marcel. Differential metabolic fate of the carbon skeleton and amino-N of 13Cand [15N]alanine ingested during prolonged exercise. J Appl Physiol 93: 499–504, 2002. First published April 5, 2002; 10.1152/japplphysiol.01195.2001.—The decarboxylation/oxidation and the deamination of 13Cand [15N]alanine ingested (1...