We have evaluated the possible role of proteoglycans in the uptake of spermine by human lung fibroblasts. Exogenous glycosaminoglycans behaved as competitive inhibitors of spermine uptake, the most efficient being heparan sulphate (Ki=0.16+/-0.04 microM). Treatment of fibroblasts with either heparan sulphate lyase, p-nitrophenyl-O-beta-D-xylopyranoside or chlorate reduced spermine uptake consid...

the sulphated form of ascorbic acid may play a role in the maintenance of connective tissue, suggested that although 35S-labelled glycosaminoglycans are formed in the presence of ascorbic acid 2-[35S]sulphate, they are not formed by direct transfer of the sulphate moiety from ascorbic acid 2-[35S]sulphate but by a decomposition product of the ester (Shapiro & Poon, 1975). The role of ascorbic a...

Background: Eclampsia is a hypertensive disorder related to pregnancy, in which there is occurrence of one or more generalized convulsions and or coma, in the absence of other neurologic conditions. It is a common obstetric emergency. Eclampsia is associated with elevated maternal and fetal morbidity and mortality. Objectives: To compare the efficacy of low dose magnesium sulphate (Dhaka) regim...

introduction: controlling parenchymal hemorrhage, especially in liver, is still one of the challenges surgeons face with when they try to save the patients’ lives despite improvements in surgical procedures. there is a research contest between the researchers in this field to introduce more effective methods. this study aimed to compare the hemostatic effect of ferric sulfate and ferric chlorid...

BACKGROUND Magnesium sulphate is a high-risk medication that is used extensively for prophylaxis and treatment of eclampsia. To accommodate recommendations related to fluid restrictions and patient safety, a protocol was developed for the administration of 20% magnesium sulphate. OBJECTIVES To determine whether administration of 20% magnesium sulphate increased the risk of phlebitis relative ...

Proteoglycans may modulate axon growth in the intact and injured adult mammalian CNS. Here we investigate the distribution and time course of deposition of a range of proteoglycans between 4 and 14 days following unilateral axotomy of the nigrostriatal tract in anaesthetised adult rats. Immunolabelling using a variety of antibodies was used to examine the response of heparan sulphate proteoglyc...

The product of the biological sulphate reduction is sulphide. High concentrations of molecular H2S (g) can be inhibitory for microbial activity, especially at a reactor pH of 6 to 7. This paper focuses on the effect of high sulphide concentrations on the sulphate reduction rates. The results of three investigations operating a continuous reactor, a column reactor and batchtest reactors have sho...

1. A polysaccharide sulphate has been isolated from the hypobranchial mucin of the whelk Buccinum undatum. 2. The molecular weight of this polysaccharide, which is a glucan carrying one ester sulphate group per monosaccharide residue, is 1.7x10(5). 3. Some investigations bearing on the location of the ester sulphate groups are reported. 4. The viscosity of the whole mucin has been shown to depe...