The objective of this study was to investigate the mechanical properties of a low-shrinkage acrylate liquid crystalline resin matrix (ALCRM), (4-3-(acryloyloxy)-2-hydroxypropoxy) phenyl 4-(3-(acryloyloxy)-2-hydroxypropoxy) benzoate, combined with nano-hydroxyapatite (na-HA). The ALCRM monomer and diluent monomer triethylene glycol dimethacrylate (TEGDMA) were mixed at a mass ratio of 7:3 to pre...

Surfaces covered with polyethylene glycol (PEG; HO-(CH(2)-CH(2)-O)(n)-H) have been shown to be biocompatible because PEG's properties yield nonimmunogenicity, nonantigenicity, and protein rejection. To produce a biocompatible surface coating, we have developed a method for grafting PEG onto activated silica films. We first deposited an amorphous silica film by plasma-enhanced chemical vapor dep...

Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology) successfully generated several FDA-approved compounds, including four blockbusters, which are considered non immunogenic. However, PEG antibodies and intolerance to the infusion were reported in some patients with gout treated with pegloticase, a PEG-uricase recently approved by the FDA (Food and Drug Ad...

† National Institute of Standards and Technology. ‡ National Institutes of Health. * To whom correspondence should be addressed. E-mail: [email protected]. Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8543, and Section on Tissue Biophysics and Biomimetics, Laboratory of Integrative and Medical Biophysics, NICHD, National Institutes of Health, B...

Streaming of gastrointestinal contents depends on the demonstration of differential rates of recovery of equal doses of two synchronously fed markers. There was no significant difference in the rate of throughput of polyethylene glycol (a liquid phase marker) and chromium sesquioxide (a solid phase marker) in healthy volunteers (n = 7) and hospital inpatients (n = 5) with normal bowel habit, so...

Bisphenol A (BPA)-recognizing imprinted polymers were synthesized using a template immobilized on silica where the template was grafted to aminopropyl silica. The silica-template conjugate was co-polymerized with a cross-linker (ethylene glycol dimethacrylate) and a functional monomer (4-vinylpyridine or methacrylic acid). The synthesized silica-polymer composites were treated with an aqueous N...

Monodisperse nonspherical poly (methyl methacrylate) (PMMA) particles where a central core particle had grown two extra "lobes", or protrusions, placed opposite each other were successfully synthesized by swelling and subsequent polymerization of cross-linked PMMA spheres with methyl methacrylate and the cross-linker ethylene glycol dimethacrylate. The use of large (~3 μm) seed particles allowe...

Molecularly imprinted polymers for dimethoate recognition were synthesized by the precipitation polymerization technique using methyl methacrylate (MMA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linker. The morphology, adsorption and recognition properties were investigated by scanning electron microscopy (SEM), static adsorption test, and competitive ads...

A mathematical model for the crosslinking copolymerization of a vinyl and divinyl monomer was developed and applied to the case of methyl methacrylate and ethylene glycol dimethacrylate batch polymerization. Model results compare favorably to the experimental findings of Li and Hamielec for the system investigated. The model presented utilizes the numerical fractionation technique and is capabl...

A novel composite of graphene sheets/Congo red-molecular imprinted polymers (GSCR-MIPs) was synthesized through free radical polymerization (FRP) and applied as a molecular recognition element to construct dopamine (DA) electrochemical sensor. The template molecules (DA) were firstly absorbed at the GSCR surface due to their excellent affinity, and subsequently, selective copolymerization of me...