Tetronasin (formerly ICI139603) [l] is a polyether polyketide antibiotic produced during the aerobic growth of the Gram-positive soil organism Streptomyces longisporofluvus. It has been used c o m i a l l y as a cattle food additive where it has been found to improve food utilisation [2] and to combat the onset of acid lactosis [3]. It may well also prove to be commercially viable as an anticwi...

Salinomycin is a carboxylic polyether ionophore which was isolated from the culture super‐ natant of the bacterium Streptomyces albus in 1974 [1]. Structurally, it is composed of a penta‐ cyclic molecule with a unique tricyclic spiroketal ring system and a unsaturated sixmembered ring (Fig. 1). Its lipophilic property enables salinomycin to act in cytoplasmic and mitochondrial membranes as an i...

A new polyether macrocyclic of 1-pyrazolylbenzimidazol-2-ones 5-6 have been synthesized by the reaction of dichloro(poly)ethylene glycol in phase transfer catalysis conditions. The structure of these compounds were identified by H NMR, C NMR, IR spectroscopy and Mass spectrometry. The formation of Li, Na, and K complexes with compounds 5-6 has been investigated by UV-visible spectroscopy. It wa...

Ferromagnetic carbon-coated cobalt nanoparticles have been ligated by a covalent or non-covalent strategy with dendrons or polymers bearing amino-, hydroxy- or polyether-functionalities, aiming at synthesizing materials that are dispersible in aqueous solutions, being a prerequisite for applications in biomedicine. Most efficiently for this purpose proved to be a covalently anchored polyethylen...

Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequenc...

We are examining surface characteristics of ultraviolet pulsed-laser micromachined structures in polymide as a function of the incident laser energy and the distance between subsequent laser spots in order to prepare surfaces for laser direct-write deposition of metals. Variations in the spot-to-spot translation distance provide an alternative means of average depth and roughness control when c...