Despite extensive research on the pathogenesis of polycystic ovary syndrome (PCOS), there is still disagreement on the underlying mechanisms. The rat model for experimentally induced polycystic ovaries (PCO)--produced by a single injection of estradiol valerate--has similarities with human PCOS, and both are associated with hyperactivity in the sympathetic nervous system. Nerve growth factor (N...

Despite extensive research on the pathogenesis of polycystic ovary syndrome (PCOS), there is still disagreement on the underlying mechanisms. The rat model for experimentally induced polycystic ovaries (PCO)—produced by a single injection of estradiol valerate—has similarities with human PCOS, and both are associated with hyperactivity in the sympathetic nervous system. Nerve growth factor (NGF...

Despite extensive research on the pathogenesis of polycystic ovary syndrome (PCOS), there is still disagreement on the underlying mechanisms. The rat model for experimentally induced polycystic ovaries (PCO)--produced by a single injection of estradiol valerate--has similarities with human PCOS, and both are associated with hyperactivity in the sympathetic nervous system. Nerve growth factor (N...

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Background Polycystic ovarian syndrome (PCOS) is the most frequent female endocrine disorder that affects 5-10% of women. PCOS is characterized by hyperandrogenism, oligo-/anovulation, and polycystic ovaries. The aim of the present research is to evaluate the expression of steroidogenic acute regulatory protein (StAR) and aromatase (CYP19) mRNA in the ovaries of an estradiol valerate (EV)-induc...

pcos (polycystic ovarian syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. fenugreek seeds extract is successfully used in lowering blood glucose. metformin has also the same effect but in a different way. the aim of this study was the assessment of fenugreek effects on insulin resistance in women with pcos.this was a prospective ...