This paper focuses on the risks of environmental carcinogenic and/or genotoxic contaminants in food. It describes, for each contaminant studied, the carcinogenicity and genotoxicity, the toxicological reference values, the exposure and the risk characterisation. The compounds studied were classified into 3 categories based on a risk assessment. Effects others than carcinogenicity and/or genotox...

The inadvertent mixing of polybrominated biphenyls (PBBs) into animal feed in 1973 resulted in the contamination of thousands of Michigan farms. Farm animals who ingested this feed suffered various consequences including weight loss, decreased productivity, frequent infections, skin changes, and reproductive abnormalities.' This error was not initially known, and widespread contamination of hum...

polychlorinated biphenyls (pcbs) have been widely used to flame-retard products common in homes and theworkplace, and subsequently. polychlorinated biphenyls (pcbs) typify a class of highly toxic, stable aromaticpollutants. pcbs are recently being scrutinized for potential environment damage in groundwater and in theatmosphere. the elimination of chemical pollutants from a contaminated environm...

The aim of this study was to determine the levels of six polychlorinated biphenyls (referred to as PCB-28, PCB-52, PCB-101, PCB-138, PCB-153 and PCB-180, according to the IUPAC) in freshwater fish from the Zagreb area. A total of 216 samples was collected from five sites: from the Sava River upstream of Zagreb, in Zagreb, and downstream of Zagreb, from Lake Jarun, and from five fishponds from t...

Two commercial polychlorinated biphenyl mixtures (Aroclor 1254 and Aroclor 1242) and one polybrominated biphenyl mixture (FireMaster BP-6) were examined for their abilities to induce hepatic microsomal monooxygenation in rainbow trout (Salmo gairdneri). Pretreatment of rainbow trout with Aroclors 1254 and 1242 (150 mg/kg IP) resulted in an approximate 10-fold induction of arylhydrocarbon (benzo...

Sex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the cerebral cortex, and the hippocampus to endocrine-disrupting chemicals (EDC). This review examines the evidence for endocrine disruption of glial-neuronal functions in the hypothalamus, hippocampus, a...