High-confidence prediction of complex traits such as disease risk or drug response is an ultimate goal of personalized medicine. Although genome-wide association studies have discovered thousands of well-replicated polymorphisms associated with a broad spectrum of complex traits, the combined predictive power of these associations for any given trait is generally too low to be of clinical relev...

Cultures of the basidiomycete Mycena avenacea TA 8480 were shown to metabolize pentachlorophenol (PCP), 2,3,5,6-tetrachloro-p-hydroquinone (TeCHQ), and 2,3,5,6-tetrachloro-p-benzoquinone (TeCBQ). The first metabolite of the PCP degradation pathway was identified as TeCBQ which in a second reaction is reduced to the hydroquinone TeCHQ. Subsequently dechlorination of TeCHQ yielded 3,5,6-trichloro...

Oxidation of 3- and 4-pentafluorosulfanyl-substituted anisoles and phenols with hydrogen peroxide and sulfuric acid provided a mixture of SF5-substituted muconolactone, maleic, and succinic acids. A plausible mechanism for the formation of the aliphatic SF5 compounds was presented and their chemical reactivity was investigated. SF5-substituted para-benzoquinone was synthesized; its oxidation le...

Substituted Benzoquinones, Photosystem II Acceptors Benzoquinones (BQ) substituted with alkyl or alkoxy groups 2,5-dimethoxy-3,6-dichloro-/>benzoquinone (DCDMQ), 2,3,5,6-tetramethoxy-/?-benzoquinone (TMQ) have been tested for their electron affinity and site of action in the photosynthetic electron transport chain in whole cells and chloroplasts. Both the substituted compounds were found to be ...

Spectrophotometric micro determination of allopurinol (ALP) via charge-transfer formation is described. This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (p-CLA) for estimation of ALP drug (act as è-donor). These reactions are applied for determination of ALP in its pharmaceutical preparations coming...

can be elucidated via molecular packing analyses of crystal structures for closely related compounds.1 2,3,5,6-Tetrafluoro1,4-benzoquinone (fluoranil) has served as a suitable acceptor for constructing donor-acceptor molecular complexes with a few polycyclic aromatic hydrocarbons (PAHs) owing to its greater electron affinity.2–4 We report herein on the crystal structure of a donor-acceptor comp...

Upon illumination, a dark-adapted photosynthetic sample shows time-dependent changes in chlorophyll (Chl) a fluorescence yield, known as the Kautsky phenomenon or the OIDPS transient. Based on the differential effects of electron acceptors such as 2,5-dimethyl-p-benzoquinone (DMQ) and 2,6-dichloro-p-benzoquinone (DCBQ) on Chl a fluorescence transients of spinach thylakoids, we suggest that the ...

The reaction of a chromene with BH(3) followed by treatment with benzoquinone and air is the key step in a direct entry to O-methyl claussequinone.