نتایج جستجو برای: platinum aluminide
تعداد نتایج: 21929 فیلتر نتایج به سال:
BACKGROUND OVA-301 is a large randomized trial that showed superiority of trabectedin plus pegylated liposomal doxorubicin (PLD; CentoCor Ortho Biotech Products L.P., Raritan, NJ, USA). over single-agent PLD in 672 patients with relapsed ovarian cancer, particularly in the partially platinum-sensitive subgroup [platinum-free interval (PFI) of 6-12 months]. This superiority has been suggested to...
The ability to design nano-structured materials presents significant future scientific and technological opportunities. To realize this potential realistic quantum mechanical simulations of real nanomaterials are required. These usually involve large problem sizes in the range of thousands to millions of atoms. Interestingly, recent advances in the locally self-consistent multiple scattering (L...
The nickeland iron-aluminide alloys are an important class of materials because of their unique resistance to oxidizing, carburizing, and sulfidizing environments at high temperatures. They also provide an interesting combination of high-temperature strength and wear resistance. Many applications have been identified for these materials including: furnace fixtures, heating elements, pumps, hydr...
The relation between chemical composition, microstructure and oxidation properties has been investigated on various FeAl based alloys, the aim being to induce changes in the microstructure of the compound by selective oxidation of aluminium. Oxidation kinetics that was evaluated on bulk specimens showed that, due to fast diffusion in the alloys, no composition gradient is formed during the alum...
UNLABELLED The PLATINUM (Protein-Ligand ATtractions Investigation NUMerically) web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures. Furthermore, PLATINUM provides a number of tools for quantitative characterization of the hydrophobic/hydrophilic match in biomolecular complexes e.g. in docking poses. These complem...
Ovarian cancer frequently acquires resistance to platinum chemotherapy, representing a major challenge for improving patient survival. Recent work suggests that resistant clones exist within a larger drug-sensitive cell population prior to chemotherapy, implying that resistance is selected for rather than generated by treatment. We sought to compare clinically derived, intrapatient paired model...
BACKGROUND Platinum-based agents are widely used in chemotherapy against solid tumors and insufficient intracellular drug accumulation is one of the leading causes of platinum resistance which is associated with poor survival of tumor patients. Thus, the detection of intracellular platinum is pivotal for studies aiming to overcome platinum resistance. In the present study, we aimed to establish...
Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Despite the advances in the treatment of OC with combinatorial regimens, including surgery and platinum-based chemotherapy, patients generally exhibit poor prognosis due to high chemotherapy resistance. Herein, we tested the hypothesis that DNA damage response (DDR) pathways are involved in resistance of OC patients to platinum...
In this study, creation of a silicon aluminide coating on IN738LC nickel-based superalloy has been investigated, using co-deposition process. Thermochemical calculations indicated the possibility of obtaining a silicon aluminide with NH4Cl activated pack powder at 900°C, in order to achieve coating with desirable structures. Two powder mixtures with nominal compositions of 7Si-14Al-(1-3) NH...
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