BACKGROUND AND PURPOSE Novel stratagems to improve the efficacy of platinum coils in occluding cerebral aneurysms have primarily involved coating coils with materials thought likely to provoke more desirable histologic reactions. No investigations to date, however, have evaluated the utility of gold or vitronectin coatings, despite known endovascular histologic effects of these agents, which ma...

BACKGROUND Although the platinum regimen is adopted widely nowadays in spite of the excessive side effects, there is still no international standard for palliative chemotherapy of advanced gastric cancer. This meta-analysis assessed the efficacy and tolerability of platinum versus non-platinum chemotherapy as first-line palliative treatment in patients with inoperable, advanced gastric cancer. ...

Nickel base superalloy alloys are used in the manufacture of gas turbine engine components, which in use are exposed to high temperatures and corrosive environments. The platinum aluminide coatings described here have been developed to protect nickel base superalloy alloys from oxidation. In this study, the effect of cyclic oxidation, platinum layer thickness and aluminizing process on beha...

the interactions between platinum complexes and human serum albumin (hsa) play crucial roles in the distribution, metabolism, and activity of platinum-based anticancer drugs. octahedral platinum (iv) complexes represent a significant class of anticancer agents that display molecular pharmacological properties different from cisplatin. in this study, the interaction between two pt(iv) complexes ...

this study was designed to assess the role of first-line chemotherapy with 5-fu and platinum in the treatment of advanced or recurrent cervical cancer, ten patients with advanced or recurrent cancer of the cervix, with no prior chemotherapy were entered in phase ii trial, from oct. 2000 to nov. 2001. eight patients were treated with cis-platinum (50 mg/m2 over 60 minutes in first day) followed ...

Platinum-based adjuvant chemotherapy improves survival among patients with lung tumors, in particular non-small cell lung cancer (NSCLC). But the predicament of drug resistance in NSCLC patients is frustrating us. The profiles of microRNAs are different between platinum chemotherapy resistant and sensitive NSCLC cells. Researches regarding microRNAs and their targets, in platinum drug resistant...

60) to be used for fabricating jewellery, so alloying additions are made to increase the hardness. Platinum jewellery alloys usually have platinum contents of 90 wt.% and higher. The most common alloys are hallmarked as 950 platinum (95 wt.%). Unlike carat gold (Au) jewellery alloys, where relatively large additions can be made (to alter the properties of the alloy such as its hardness or colou...

Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in...

2-Borylated porphyrins reacted with Pt(cod)Cl2 to give b-to-b platinum-bridged porphyrin dimers, which were converted to b-to-b directly linked porphyrin dimers through triphenylphosphine-mediated reductive elimination. Similar reactions of 2,18-diborylated Ni(II)–porphyrin and Zn(II)–porphyrin gave the corresponding doubly b-to-b platinum-bridged porphyrin dimers. Treatment of the doubly b-to-...