Clinical evidence suggests that individuals with factor VIII (FVIII) deficiency (hemophilia A) are protected against venous thrombosis, but treatment with recombinant proteins can increase their risk for thrombosis. In this study we examined the dynamics of thrombus formation in individuals with hemophilia A and their response to replacement and bypass therapies under venous flow conditions. Fi...

In the present case of a 35-year old patient, platelet-rich fibrin, which is an autologous platelet concentrate, was used to fill the osseous defect following surgery. The case was assessed both clinically and radiographically for a period of 9 months.

This case series reports the various treatment modalities to treat multiple recessions. Gingival recession is a widespread clinical manifestation affecting single or root surfaces at all teeth types. Periodontal reconstructive surgery consists of mucogingival procedures. The primary goal these procedures benefit periodontal health through reconstruction lost hard and soft tissues, by preventing...

The effects on thrombosis and hemostasis of thrombin-induced activation of endogenous protein C (PC) were evaluated in baboons. Thrombosis was induced by placing into arteriovenous shunts a segment of Dacron vascular graft, which generated arterial platelet-rich thrombus, followed by an expansion region of low-shear blood flow, which in turn accumulated fibrin-rich venous-type thrombus. Thrombo...

The authors describe a new material termed mineralized plasmatic matrix (MPM), a combination of platelets, fibrin concentrate, and autogenous bone to repair alveolar cleft defects. Autogenous cancellous bone is widely used to this end because such bone affords the functionalities (osteogenesis, osteoinduction, and osteoconduction) required for successful outcomes. To optimize these features, au...

Abstract Introduction The relevance of this study lies in the fact, that today search for biocompatible materials management bone defects is importance. Such could become an alternative to transplants. For replacement defects, two-phasic bioactive ceramics hydroxyapatite and β-tricalcium phosphate a very attractive biomaterial due its excellent biocompatibility osteoconductivity, but results us...