نتایج جستجو برای: platelet adhesion

تعداد نتایج: 194154  

Journal: :Blood 2006
Ton Lisman Nicolas Raynal Dafna Groeneveld Ben Maddox Anthony R Peachey Eric G Huizinga Philip G de Groot Richard W Farndale

The essential event in platelet adhesion to the injured blood vessel wall is the binding to subendothelial collagen of plasma von Willebrand factor (VWF), a protein that interacts transiently with platelet glycoprotein Ibalpha (GPIbalpha), slowing circulating platelets to facilitate firm adhesion through collagen receptors, including integrin alpha2beta1 and GpVI. To locate the site in collagen...

Journal: :Journal of biomedical materials research 1987
G H Engbers L Dost W E Hennink P A Aarts J J Sixma J Feijen

The adhesion of human blood platelets onto vascular catheters was studied using a specially designed perfusion chamber. Polyurethane catheters were exposed to citrated human blood for different periods (up to 20 min) and at different wall shear rates (190, 260, 330 sec-1). The rate of platelet adhesion was determined using 111In-labeled platelets, while the morphology of adhering platelets was ...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2013
Liza U Ljungberg Karin Persson Andreas C Eriksson Henrik Green Per A Whiss

Cigarette smoking is a leading cause of cardiovascular disease. The cardiovascular effects of smoking are probably multifactorial, including effects on platelets. Previous reports investigating the effects of nicotine and tobacco on platelet function are inconsistent. The present study investigated in vitro effects of nicotine, its major metabolites, tobacco extracts and extract of tobacco-free...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Yongzhi Qiu Ashley C Brown David R Myers Yumiko Sakurai Robert G Mannino Reginald Tran Byungwook Ahn Elaissa T Hardy Matthew F Kee Sanjay Kumar Gang Bao Thomas H Barker Wilbur A Lam

As platelets aggregate and activate at the site of vascular injury to stem bleeding, they are subjected to a myriad of biochemical and biophysical signals and cues. As clot formation ensues, platelets interact with polymerizing fibrin scaffolds, exposing platelets to a large range of mechanical microenvironments. Here, we show for the first time (to our knowledge) that platelets, which are anuc...

Journal: :Blood 1990
T M Alkhamis R L Beissinger J R Chediak

Red blood cell (RBC) effects on platelet adhesion to a nonbiologic test surface (tetrafluoroethylene propylene copolymer) and platelet aggregation during laminar shear flow for shear rates to 5,680 s-1 (corresponding to shear stress to 200 dyne/cm2) were investigated. Results on hemoglobin (Hb) and adenosine diphosphate (ADP) release from RBCs, percent decrease of single platelets in the bulk, ...

2015
Nicholas Pugh Dominique Bihan David J. Perry Richard W. Farndale

Platelet activation is traditionally quantified using turbidimetric aggregometry, which reflects integrin αIIbβ3 activity, an important determinant of platelet function during pathophysiological thrombus formation. However, aggregometry does not recreate the shear conditions prevailing during thrombosis in vivo. Here we describe novel whole-frame analysis of real-time video microscopy to quanti...

Journal: :The Biochemical journal 1992
J B Smith C Dangelmaier M A Selak B Ashby J Daniel

The adhesion of platelets to collagen and their activation is the primary event in haemostasis. Following adhesion, platelet aggregation mediated by ADP, thromboxane A2 and thrombin leads to the formation of a platelet plug. It is known that platelet activation by each of these agonists involves an increase in the cytosolic free Ca2+ concentration, and this has been thought to be controlled by ...

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