The subfragment 2/light meromyosin "hinge" region has been proposed to significantly contribute to muscle contraction force and/or speed. Transgenic replacement of the endogenous fast muscle isovariant hinge A (exon 15a) in Drosophila melanogaster indirect flight muscle with the slow muscle hinge B (exon 15b) allows examination of the structural and functional changes when only this region of t...

We propose random hinge forests, a simple, efficient, and novel variant of decision forests. Importantly, random hinge forests can be readily incorporated as a general component within arbitrary computation graphs that are optimized endto-end with stochastic gradient descent or variants thereof. We derive random hinge forest and ferns, focusing on their sparse and efficient nature, their min-ma...

The two distinct domains of flavocytochrome b2 (L-lactate:cytochrome c oxidoreductase) are connected by a typical hinge peptide. The amino acid sequence of this interdomain hinge is dramatically different in flavocytochromes b2 from Saccharomyces cerevisiae and Hansenula anomala. This difference in the hinge is believed to contribute to the difference in kinetic properties between the two enzym...

We investigated whether improvements in design have altered the outcome for patients undergoing endoprosthetic replacement of the distal femur after resection of a tumour. Survival of the implant and 'servicing' procedures have been documented using a prospective database, review of the design of the implant and case records. In total, 335 patients underwent a distal femoral replacement, 162 ha...

the nonlinear static pushover analysis technique is mostly used in the performance-based design of structures and it is favored over nonlinear response history analysis. however, the pushover analysis with fema load distributions losses its accuracy in estimating seismic responses of long period structures when higher mode effects are important. some procedures have been offered to consider thi...

In this study, constant-ductility optimization algorithm under a family of earthquake ground motions is utilized to achieve uniform damage distribution over the height of steel moment resisting frames (SMRFs). SMRF structures with stiffness-degrading hysteric behavior are modeled as single-bay generic frame in which the plastic hinge is confined only at the beam ends and the bottom of the first...

Abstract Under strong earthquakes, reinforced concrete (RC) walls in high-rise buildings, particularly wall piers that form part of a coupled or core system, may experience axial tension–flexure loading. In this study, detailed finite element model was developed VecTor2 to provide an effective tool for the further investigation seismic behaviour RC subjected tension and cyclic lateral The verif...