To evaluate the roles of hyperglycemia and increased plasma FFA level in the development of insulin resistance, we examined the effects of phlorizin and acipimox treatments on tissue sensitivity to insulin in streptozotocin(STZ)-diabetic rats. Insulin sensitivity was assessed with the glucose-insulin clamp technique. Blood glucose concentration was clamped at basal levels of control and diabeti...

Six growing pigs (30-75 kg) were fed on semi-purified diets containing either 30 g maize oil/kg diet (LFM), 30 g soya-bean oil-tallow mixture (1:1, w/w)/kg diet (LFST) or 160 g soya-bean oil-tallow mixture (1:1, w/w)/kg diet (HFST) without and with the addition of guar gum (40 g/kg diet). Plasma glucose and insulin concentrations following twice daily feeding at 09.00 and 21.00 h were measured,...

objectives insulin resistance has been considered as the most important component of type 2 diabetes mellitus (dm2). plants used in folk medicine to treat diabetes mellitus represent a viable alternative for the control of this disease. this study was aimed to examine the antidiabetic effects of three iranian medicinal plants i.e. urtica dioica, trigonella foenum-graecum and fumaria officinalis...

BACKGROUND Regulation of plasma glucose concentration for type 1 diabetic patients is challenging, and exercise is an added complication. From a metabolic prospective, the significant exercise-induced effects are increased glucose uptake rate by the working tissues, increased hepatic glucose release to maintain overall glucose homeostasis, and decreased plasma insulin concentration. During prol...

BACKGROUND Colorectal cancer and type 2 diabetes share many risk factors, and hyperinsulinemia appears to be associated with an increased risk of colorectal cancer. We used the concentration of plasma C-peptide (an indicator of insulin production) to determine whether insulin and insulin resistance are associated with the risk of developing colorectal cancer. METHODS We conducted a nested cas...

background and objective: obesity is an independent risk factor for cardiovascular diseases and diabetes. the abnormalities involved may be mediated by increased secretions of inflammatory proteins called adipocytokines by the adipose tissue. thus, monitoring adipocytokines during weight loss could be helpful in progress evaluation of weight reduction programs. since high-protein diets are cons...

CONTEXT Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. OBJECTIVE We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES:...

OBJECTIVE We sought to assess insulin secretion/insulin resistance index in predicting the risk for future type 2 diabetes RESEARCH DESIGN AND METHODS A total of 1,551 nondiabetic subjects from the San Antonio Heart Study received an oral glucose tolerance test (OGTT) with measurement of plasma glucose and insulin concentrations at 0, 30, 60, and 120 min at baseline and after 7-8 years of fol...