OBJECTIVE A randomised double-blind placebo controlled withdrawal clinical trial of prednisone versus placebo in patients with rheumatoid arthritis (RA), treated in usual clinical care with 1-4 mg/day prednisone, withdrawn to the same dose of 1 mg prednisone or identical placebo tablets. METHODS All patients were from one academic setting and all trial visits were conducted in usual clinical ...

objective: there are some studies about the good effects of herbal medicine on blood glucose. this study was designed to evaluate the synergism effect of peganum harmala (p.harmala), quercus infectoria (q.i), vaccinium myrtillus (v.myrtillus), citrullos colocynthis (c.colocynthis), securigera securidaca (s.s) on blood glucosein type 2 diabetic patients. materials and methods: twenty four type 2...

Abstract Background Acute severe ulcerative colitis (ASUC) is a manifestation of (UC) that requires hospitalisation. Despite significant advances in therapeutic options for UC and the medical management steroid-refractory ASUC, initial treatment paradigm ASUC has not changed since 1950s based on use intravenous (IV) corticosteroids. Approximately 50% patients do respond require further or surgi...

Abstract Background Myocardial injury of ST-segment elevation myocardial infarction (STEMI) initiates an intense inflammatory response that contributes to further damage and is a predictor increased risk death or heart failure (HF). Interleukin-1 (IL-1) key mediator local systemic damage. We postulate the use drug RPH-104, which selectively binds inactivates both α β isoforms IL-1 will lead dec...

Background: ZY-19489 is a triaminopyrimidine comprising the novel antimalarial class. Methods: This was phase-1, two-part double-blind, placebo-controlled study conducted in Ahmedabad, India. Part-1 single-dose singlecohort study. Part-2 multiple-ascending-dose Healthy participants aged 18-55 years were included. The primary objective to evaluate safety and tolerability of healthy adult Indian...

OBJECTIVE To assess efficacy and safety of lixisenatide monotherapy in type 2 diabetes. RESEARCH DESIGN AND METHODS Randomized, double-blind, 12-week study of 361 patients not on glucose-lowering therapy (HbA(1c) 7-10%) allocated to one of four once-daily subcutaneous dose increase regimens: lixisenatide 2-step (10 μg for 1 week, 15 μg for 1 week, and then 20 μg; n = 120), lixisenatide 1-step...

Physical complaints, such as pain, can be effectively reduced by placebo effects through induction of positive expectations, or increased by nocebo effects through induction of negative expectations. In the present study, verbally induced nocebo and placebo effects on itch were experimentally investigated for the first time. In part 1, the role of verbal suggestions in inducing nocebo effects o...

Background Allergic rhinitis induced by house dust mites (HDMs) is a highly prevalent but often underdiagnosed and undertreated/untreated chronic disease. It has negative impact on sleep, work, leisure activities, health-related quality of life. Allergen immunotherapy proven, safe treatment for respiratory allergies. Objective We sought to assess the efficacy safety 300 index reactivity (IR) su...