Solid core polymeric particles are an attractive delivery vehicle as they can efficiently encapsulate drugs of different physical and chemical characteristics. However, the effective targeting of such particles for therapeutic purposes has been somewhat elusive. Here, we report novel polymeric particles comprised of poly(lactic acid) (PLA) with incorporated poly(ethylene glycol)-lipids (PEG-lip...

Purpose This paper aims to develop a novel strategy manufacture poly-lactic acid (PLA) filaments reinforced with Mg particles for fused filament fabrication of porous scaffolds biomedical applications. Design/methodology/approach The mixture PLA pellets and was extruded twice, the second time using precision extruder that produces zero porosity, constant diameter homogeneous dispersion particle...

Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or ...

Phase change materials (PCMs) are promising thermal energy storage due to their high specific latent heat. Conventional PCMs typically exploit the solid–liquid (s–l) transition. However, leakage and leaching common issues for PCMs, which have be addressed before usage in practical applications. In contrast, solid–solid (s–s) would naturally overcome these inherent form stability homogeneity. th...

A new polymeric construct is proposed as a starting material for liver-targeted delivery system in the present communication. The has been designed to be sensitive pH variations and potentially loaded with hydrophobic antitumoral agents. It based on one of most used copolymers field nanomedicine: PEG-PLA. latter, usually obtained by polymerization lactic acid hydroxyl-terminated polyether, asse...

Biodegradable materials have attracted considerable attention to be applied in maintaining food quality and safety due their ability of a sustained release antimicrobial agents. In this study, cinnamon essential oil (CEO) loaded poly (ethylene glycol)-poly (?-caprolactone) (PEG-PCL) micelles (CEO-micelles) were prepared for humidity-controlled CEO preservation strawberry quality. The CEO-micell...

We examined the therapeutic activity of betamethasone disodium 21-phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly (D,L-lactic/glycolic acid) (PLGA)/poly(D,L-lactic acid) (PLA) homopolymers and polyethylene glycol (PEG)-block-PLGA/PLA copolymers (stealth nanosteroid) in experimental arthritis models. Various stealth nanosteroids with a size of 45 to 1...

PURPOSE Polycaprolactone (PCL) is a biodegradable polyester and has attracted attention as a suitable carrier for development of controlled drug delivery due to its non-toxicity and biocompatibility. It has been reported that the biodegradability of PCL can be enhanced by copolymerization with PEG. Molecular weight (Mw) and CL block lengths optimization in a series of synthesized PCEC copolymer...