نتایج جستجو برای: pka

تعداد نتایج: 9744  

Journal: :The Journal of Cell Biology 2004
Katja Köhler Daniel Louvard Ahmed Zahraoui

The GTPase Rab13 regulates the assembly of functional epithelial tight junctions (TJs) through a yet unknown mechanism. Here, we show that expression of the GTP-bound form of Rab13 inhibits PKA-dependent phosphorylation and TJ recruitment of the vasodilator-stimulated phosphoprotein, an actin remodelling protein. We demonstrate that Rab13GTP directly binds to PKA and inhibits its activity. Inte...

2013
Gesa Schäfer Jelena Milić Adeeb Eldahshan Frank Götz Kerstin Zühlke Christian Schillinger Annika Kreuchwig Jonathan M Elkins Kamal R Abdul Azeez Andreas Oder Marie C Moutty Nanako Masada Monika Beerbaum Brigitte Schlegel Sylvia Niquet Peter Schmieder Gerd Krause Jens Peter von Kries Dermot M F Cooper Stefan Knapp Jörg Rademann Walter Rosenthal Enno Klussmann

Protein kinase A (PKA) is a ubiquitous kinase that phosphorylates a broad variety of substrates. A-kinase anchoring proteins (AKAPs) confer specificity to PKA signaling by tethering the kinase to distinct cellular compartments, thereby limiting the access of PKA to a defined pool of its substrates. Interactions between AKAPs and PKA play key roles in a plethora of physiologically relevant proce...

Journal: :Journal of neurophysiology 2000
N H Woo S N Duffy T Abel P V Nguyen

cAMP-dependent protein kinase (PKA) is believed to play a critical role in the expression of long-lasting forms of hippocampal long-term potentiation (LTP). Can distinct patterns of synaptic activity induce forms of LTP that require different isoforms of PKA? To address this question, we used transgenic mice that have genetically reduced hippocampal PKA activity, and a specific pharmacological ...

2010
Jiangchuan Tao Hsien-yu Wang Craig C Malbon

BACKGROUND The cAMP-dependent protein kinase A (PKA) plays a pivotal role in virtually all cells, there being a multitude of important target molecules that are substrates for PKA in cell signaling. The spatial-temporal dynamics of PKA activation in living cells has been made accessible by the development of clever biosensors that yield a FRET signal in response to the phosphorylation by PKA. A...

2013
Kelly A. Kaihara Lorna M. Dickson David A. Jacobson Natalia Tamarina Michael W. Roe Louis H. Philipson Barton Wicksteed

Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phase insulin secretion and improve glucose control. To determine the physiological role of the cAMP-dependent protein kinase (PKA), a mouse model was d...

Journal: :Infection and immunity 2012
Laura J MacDonald Richard C Kurten Daniel E Voth

Coxiella burnetii is the bacterial agent of human Q fever, an acute, flu-like illness that can present as chronic endocarditis in immunocompromised individuals. Following aerosol-mediated transmission, C. burnetii replicates in alveolar macrophages in a unique phagolysosome-like parasitophorous vacuole (PV) required for survival. The mechanisms of C. burnetii intracellular survival are poorly d...

Journal: :The Journal of biological chemistry 2009
Adriana A Paulucci-Holthauzen Leoncio A Vergara Larry J Bellot David Canton John D Scott Kathleen L O'Connor

Protein kinase A (PKA) has been suggested to be spatially regulated in migrating cells due to its ability to control signaling events that are critical for polarized actin cytoskeletal dynamics. Here, using the fluorescence resonance energy transfer-based A-kinase activity reporter (AKAR1), we find that PKA activity gradients form with the strongest activity at the leading edge and are restrict...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Robyn D Moir JaeHoon Lee Rebecca A Haeusler Neelam Desai David R Engelke Ian M Willis

Maf1 is an essential and specific mediator of transcriptional repression in the RNA polymerase (pol) III system. Maf1-dependent repression occurs in response to a wide range of conditions, suggesting that the protein itself is targeted by the major nutritional and stress-signaling pathways. We show that Maf1 is a substrate for cAMP-dependent PKA in vitro and is differentially phosphorylated on ...

Journal: :F1000Research 2020

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