Paraneoplastic syndromes of hepatocellular carcinoma (HCC) are not uncommon. However, the prognosis is poor and follow-up and improvement of paraneoplastic syndromes with treatment have been reported rarely. We report a successful case in an aged man of a massive HCC with paraneoplastic syndrome, treated by combined intraarterial chemotherapy and hepatic resection. Paraneoplastic syndrome (eryt...

For treating hepatocellular carcinoma (HCC), radiofrequency ablation (RFA), a nonsurgical locoregional therapy, is frequently chosen as the first treatment modality because it is effective and less invasive, with preservation of the remnant hepatic parenchyma. Tumor implantation along needle tract or on other sites is a rare complication of RFA. We present a patient with HCC who developed a dro...

We report herein a case of idiopathic adrenal hematoma. A 59-year-old Japanese man was referred to our hospital for evaluation of a 7.0 cm mass in the right upper abdominal cavity. The tumor was suspected to originate from either the posterior segment of the liver or the right adrenal gland. His chief complaint was weight loss of 8 kg over the previous 6 months. He had no past medical history a...

Purpose: The tumor suppressor gene p16 is mainly inactivated by an epigenetic change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical impact of p16 methylation and the potential risk factors for this epigenetic alteration have not been thoroughly investigated. Experimental Design: We studied the methylation status and mRNA and protein expression of p16 in 50 he...

BACKGROUNDS/AIMS Hepatocellular carcinoma (HCC) is uncommon in young adults and the prognosis of these patients is still unclear. In this retrospective study, we compared the clinicopathological characteristics and outcomes of young patients with HCC with those of older patients with HCC. METHODS We retrospectively reviewed the clinicopathological characteristics of a total of 1,124 patients ...

Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S-warfarin plasma levels and international normalized ratio were obtained to serve as inputs to a ...

It was shown by Jackson and Grosu [1995a] that entrainment control of a complex dynamic system could be achieved by using an open-plus-closed-loop (OPCL) control action. Jackson [1995] showed that, for multiple-attractor systems, it is also possible to transfer the dynamics of a system between arbitrary attractors, using this control only for a limited period of time (“migration control”). In t...