Peptide immunotherapy (PIT) offers realistic prospects for the treatment of allergic diseases, including allergic asthma. Much is understood of the behavior of naive T cells in response to PIT. However, treatment of patients with ongoing allergic disease requires detailed understanding of the responses of allergen-experienced T cells. CD62L expression by allergen-experienced T cells corresponds...

Antibody-based photodynamic therapy, or photoimmunotherapy (PIT), is a novel, targeted cancer therapy, which can serve as both a diagnostic and a therapeutic agent. The primary objective of this study was to evaluate the capacity of panitumumab-IRDye700DX (Pan-IR700) to eliminate microscopic tumor remnants in the postsurgical setting, which was accomplished using novel in vitro and in vivo mode...

Near Infrared-Photoimmunotherapy (NIR-PIT) is a new, highly selective tumor treatment that employs an antibody-photon absorber conjugate (APC). When the APC attaches to its target cell and is exposed to NIR light, highly selective cell killing is observed. NIR-PIT has been demonstrated with a limited number of antibodies. Mesothelin is overexpressed in several malignancies and is emerging as a ...

The usefulness of magnifying endoscopy was assessed by examining the extent to which a magnifying endoscope can provide images of pits and by analyzing the consistency of the pit patterns visualized by magnifying endoscopy with the pit patterns visible under a stereomicroscope. Study materials consisted of 83 cases of tumorous colorectal lesions. Under a magnifying endoscope, pits were visible ...

BACKGROUND Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping ongoing thought and behavior. The influence of pavlovian stimuli on ongoing behavior is paradigmatically measured by pavlovian-to-instrumental transfer (PIT) tasks. These involve multiple stages and are complex. Whether incr...

OBJECTIVES To observe the effectiveness and mechanisms of physiological ischemic training (PIT) on brain cerebral collateral formation and functional recovery in patients with acute cerebral infarction. METHODS 20 eligible patients with acute cerebral infarction were randomly assigned to either PIT group (n = 10) or Control group (n = 10). Both groups received 4 weeks of routine rehabilitatio...

UNLABELLED The purpose of this study was to assess the clinical spectrum of asymptomatic abnormal focal uptake of (99m)Tc-methylene diphosphonate (MDP) in the femoral neck. METHODS Fifteen consecutive patients with asymptomatic abnormal focal uptake of (99m)Tc-MDP in the femoral neck were evaluated. Two patients had bilateral abnormal focal uptake. The patient's history, clinical findings, an...

Objective The aim of this study was to evaluate the retention of glass ionomer sealant, Vitro Molar® (DFL) and Ketac Molar Easy Mix® (3 m ESPE) as pit and fissure sealants on first permanent molars, fully or partially erupted. Methods The study sample consisted of 412 molars, among 110 children. The sealant retention was evaluated after 6 months of the application. Results The results were coll...

[1] Mars Orbiter Camera images are used to identify widespread material interpreted to have formed via explosive volcanism on Arsia Mons volcano, Mars. This material crops out in cliff sections associated with pit craters in layers 45– 50 m thick. The large range of elevations where the material is found (6.2–17.5 km) suggests locally-derived materials, although extensive reworking has produced...

River bed sand and gravel are utilized more than mountain materials due to their availability and closeness to the transit roads and sites of usage. Excessive and non-technical extraction of gravel and sand bring a kind of interference in them, leading to many negative consequences. Therefore, presenting solutions to reduce these impacts and infilling mining pits are essential. In this researc...