Cerebral ischemia (CI), caused by the deprivation of oxygen and glucose to the brain, is the leading cause of permanent disability. Neuronal demise in CI has been linked to several pathways which include cyclooxygenases (COX) - mediated production of prostaglandins (PGs) and subsequently reactive oxygen species (ROS), aquaporin-4 (AQ-4) - mediated brain edema and acidsensing ion channel-1a (ASI...

Piroxicam has two different crystalline forms (known as needle and cubic forms), that they are different in physicochemical properties such as biological solubility. In the current research, using Taguchi experimental design approach the influences of five operating variables on formation of the piroxicam polymorph shapes in recrystallization were studied. The variables include type of solvent,...

In this work, the solubility of a non-steroidal anti-inflammatory drug (NSAID), piroxicam, is investigated. The polymorphic form II, which most stable at room temperature, was investigated in seven different solvents with various polarities. It has been found that piroxicam following order: chloroform > dichloromethane acetone ethyl acetate acetonitrile acetic acid methanol hexane. Crystalli...

in this work, a new spectrophotometric method for the determination of trace amount of cobalt (іі) ionwas investigated and the stability constant of the related complex was evaluated 2.174 × 104. in the cobalt(іі)-piroxicam complex, the maximum absorbance wavelength is 570 nm and the linearity of calibrationcurve was investigated (5-10 ppm). the relative standard deviation for seven replicate e...

In this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug. Among the synthesized analogues, compounds 14f (LASSBio-1637) and 14g (LASSBio-1639) were identified as novel antinociceptive and anti-inflammatory prototy...

Rifampicin is known to influence the metabolic disposition of other drugs because of its 'enzyme inducing' effects in the liver (1, 6). The microsomal enzymes catalyze glucuronide conjugations and most of the oxidation of the drugs. Reduction and hydrolysis of drugs are catalyzed by both microsomal and non-microsomal enzymes (3). Hydroxylation and glucuronide formation are involved in the metab...

The purpose of the present study was to investigate the contribution of prostaglandins (PGs) synthesized by constitutive (COX-1) and inducible (COX-2) cyclooxygenase to stimulation of the hypothalamic-pituitary-adrenal (HPA) axis by adrenergic receptor agonists in rats under social crowing stress 3 days, (21 per a cage for 6) animals. The effects of phenylephrine, clonidine and isoprenaline, an...